• Supports a calm mood
      • Supports sleep


The Ziziphus jujuba is indigenous to many parts of South Asia.


In Traditional Chinese Medicine (TCM), the fruits and seeds of this plant are used to relieve stress and calm the mind and spirit. Ziziphus spinosa, Semen Ziziphi spinosae, and Suanzaoren are some of the names of the seeds in research.


This is why the seeds are widely used in China and other parts of Asia to support sleep and relaxation.


Suanzaoren formula, named for Z.jujuba seeds, is one of the most popular herbal formulations in TCM for sleep and mood support. It contains five herbs and is called Suan Zao Ren Tang because Z.jujuba seeds have a prominent role in the recipe.


There are several active ingredients included in the combo, including flavonoids (including swertisin and spinosin), saponins (jujubosides), and polysaccharides. [2].

Its traditional calming and sleep-inducing properties seem to result primarily from saponins and flavonoids.*


Stress and sleep


  • Supports sleep [1,3–5]

  • Supports sleep time [6–12]

  • Supports slow-wave sleep (SWS) [11]

  • Supports healthy behavioral and physiological responses to stress [8,13–16]

  • Supports stress hormone levels [16]


Brain function


  • Supports GABAergic neurotransmission [7,12,13,15,17,18]

  • Supports glutamatergic neurotransmission [18,19]

  • Supports serotonergic neurotransmission [4,15,18]

  • Supports noradrenergic neurotransmission [18]

  • Supports dopaminergic neurotransmission [18]

  • Downregulates acetylcholinesterase (AChE) activity [20]

  • Supports choline acetyltransferase (ChAT) [21]

  • Inhibit adenosine deaminase (ADA) (liver) [22]

  • Supports glutamic acid decarboxylase (GAD) [12,13]

  • Supports brain-derived neurotrophic factor (BDNF) [23–25]

  • Supports neurogenesis [24,26]

  • Supports long-term potentiation [25,27]

  • Supports synaptic transmission [19]

  • Supports neuroprotective functions [20,21,23,25,27,28]

  • Supports antioxidant defenses [20,23]


Gut microbiota


  • Modulates the gut microbiota [29,30]

  • Modulates gut-immune signaling [17,30]

  • Modulates microbial metabolism (short-chain fatty acids [SCFAs]) [30]


Complementary ingredients


  • With 5-Hydroxytryptophan (5-HTP) to support sleep [9]


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