• Supports eye health
        • Supports upper respiratory health
        • Supports general immune health


The trace mineral zinc (Zn) has been known as an essential trace mineral since 1963. It is a component of over 300 enzymes and transcription factors (i.e., genes that control other genes).


Zinc is found in large quantities throughout the body, including in the adrenal glands, brain, eyes, muscle, pancreas, bones, kidney, and liver [2].


Health-related functions of zinc include antioxidant defenses, brain function, metabolic function, and men's and women's health functions [1].


Among its important functions, zinc supports both innate and adaptive immune cells and is essential for mucosal immunity, immune tolerance, and immune communication [3,4].


Zinc deficiency is fairly common [5]. Zinc deficiency can impair healthy immune cell function even if it is mild to moderate [4,6,7].


There are many foods rich in zinc, including oysters, fish, poultry, meat, wheat germ, molasses, lentils, nuts, and seeds. In developed countries, zinc can also be fortified into cereal grains [5].


Intense exercise, vegetarian diets, high alcohol consumption, and elderly age are associated with poor zinc status.


Dietary supplements contain a variety of zinc compounds. Studies have proved that zinc gluconate is among the best forms of zinc for absorbing and enhancing immunity.

This zinc salt of gluconic acid contains two molecules of gluconic acid for every zinc cation (Zn2+).


Immune function


  • Supports general immune health [9–16]
  • Supports innate immunity [17–20]
  • Supports adaptive immunity [10,11,21–23]
  • Supports mucosal immunity [24–26]    
  • Supports immune tolerance [27–37]
  • Supports immune signaling [38–43]
  • Supports healthy dendritic cell function [37,44]
  • Supports healthy neutrophil function [17]
  • Supports healthy macrophage function [3,18,45]
  • Supports healthy T cell function [7,10,11,21–23,46,47]
  • Supports healthy NK cell function [19,20,48,49]
  • Supports healthy B cell function [10]


Healthy aging


  • Supports Nrf2 [50–62]
  • Supports redox homeostasis [63–65]
  • Supports antioxidant defenses [63–66]


Brain function


  • Supports a balanced mood [67–71]
  • Supports cognitive function [72,73]
  • Supports brain-derived neurotrophic factor (BDNF) [74–76]
  • Supports sleep [77–79]
  • Supports eye health [80–82]


Complementary ingredients


  • Selenium in supporting immunity [83,84]
  • In human research studies, it is not uncommon for small amounts of copper to be included when dosing zinc in amounts in excess of the tolerable upper limits. But in human studies where zinc has been supplemented in amounts close to the daily value levels, it is unusual to find copper supplemented in combination with zinc.
  • Large amounts of supplemental iron (greater than 25 mg) might decrease zinc absorption [85]


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