GET 15% OFF WHEN YOU START A RECURRING ORDER! USE CODE "START" IN CHECKOUT. CANCEL ANYTIME!

VITAMIN D3 (CHOLECALCIFEROL) BENEFITS

KEY BENEFITS OF VITAMIN D3

        • Supports cardiovascular health
        • Supports upper respiratory health
        • Supports cognitive function
        • Supports bone health
        • Supports general immune health
        • Supports a healthy mood

ABOUT VITAMIN D3

Vitamin D is an essential fat-soluble vitamin. It is found in animal foods—fatty fish are a good source—where, because it is fat-soluble, it concentrates in fat.

 

But a large amount of the body stores of vitamin D are not obtained from the diet; it is produced from skin exposure to sunlight. This is true for humans and animals.

 

In addition to fatty fish, other animal foods such as dairy and eggs will have varying amounts of vitamin D depending on whether the food has been fortified with vitamin D (most milk has been) and whether the animal the product originated from had sufficient exposure to sunlight (or ate food that did).

 

In addition to milk, some milk alternatives (such as beverages made from soy, almond, or oats), ready-to-eat breakfast cereals, orange juices, margarine and other food products can be fortified with vitamin D.

 

Mushrooms can also be a good source of vitamin D, but again this will be dependent on their exposure to sunlight.

 

Vitamin D is usually supplemented as either vitamin D2 (Ergocalciferol) or D3 (Cholecalciferol).

 

Of the two, vitamin D3 is considered superior for supporting healthy vitamin D levels[1].

Vitamin D is essential for general health and is especially important for supporting the health of bones, the brain and nervous system, the heart, and the immune system.


VITAMIN D3 FULL BENEFITS

Brain function

 

  • Supports memory[4,5]
  • Supports working memory[6]
  • Protects from cognitive impairment[7–9]
  • Supports the expression of neurotrophic factors (NT-3, BDNF, GDNF, CNTF, and NGF)[10–12]
  • Supports neurogenesis[6,10]
  • Supports neuronal structure[13–15] [7,16]
  • Modulates brain antioxidant defenses and oxidative stress[7,17–19]
  • Modulates neural cytokine signaling[7,14,20]
  • Supports neuroprotective functions[7,13,17,18,21,22]

 

Mood

 

  • Supports positive affect[19,23–25]
  • Supports a calm/relaxed mood[24–26]

 

Immunity

 

  • Supports general immune health[3,27,28]
  • Supports innate immunity[29,30]
  • Supports adaptive immunity[31–38]
  • Supports mucosal immunity[39–47]   
  • Supports immune tolerance[31,33–38,48–52]
  • Supports immune balance[31,53]
  • Supports healthy dendritic cell function[29,30]
  • Supports healthy natural killer cell function[30]
  • Supports healthy microglia function[14,54–59]
  • Supports healthy T cell function[31–38]
  • Supports healthy B cell function[31,33,34,48–51]  

 

Gut microbiota

 

  • Supports a healthy gut microbiota[60–66]

 

Cardiometabolic health

 

    • Supports healthy cardiovascular function[67–70]
    • Supports healthy insulin levels[19,71,72]
    • Supports healthy glucose levels[19]

 

Healthy aging

 

    • Supports balance during aging (i.e., may help reduce risk of falls)[73,74]
    • Supports healthy bone function during aging[74,75]
    • Supports healthy muscle function during aging[74]
    • Supports healthspan extension (Caenorhabditis elegans)[76]
    • Supports mitochondrial function[77,78]  
    • Supports Nrf2 function[79–86]

 

Complementary ingredients

 

    • Vitamin D is involved in intestinal absorption and homeostasis of minerals such as calcium and magnesium[87,88]
    • Vitamin K is potentially complementary to vitamin D[89]

VITAMIN D3 CAN BE FOUND IN:

Morning Momentum

Get Instant Access To A Simple, Proven System That Has Helped

THOUSANDS of People

IGNITE Their Health and Energy

to Create The Life They Deserve!

Learn More


REFERENCES

[1] P. Autier, S. Gandini, P. Mullie, J. Clin. Endocrinol. Metab. 97 (2012) 2606–2613.
[2] C.A. Reider, R.-Y. Chung, P.P. Devarshi, R.W. Grant, S. Hazels Mitmesser, Nutrients 12 (2020).
[3] A.R. Martineau, D.A. Jolliffe, L. Greenberg, J.F. Aloia, P. Bergman, G. Dubnov-Raz, S. Esposito, D. Ganmaa, A.A. Ginde, E.C. Goodall, C.C. Grant, W. Janssens, M.E. Jensen, C.P. Kerley, I. Laaksi, S. Manaseki-Holland, D. Mauger, D.R. Murdoch, R. Neale, J.R. Rees, S. Simpson, I. Stelmach, G. Trilok Kumar, M. Urashima, C.A. Camargo, C.J. Griffiths, R.L. Hooper, Health Technol. Assess. 23 (2019) 1–44.
[4] J.A. Pettersen, Exp. Gerontol. 90 (2017) 90–97.
[5] H. Darwish, R. Haddad, S. Osman, S. Ghassan, B. Yamout, H. Tamim, S. Khoury, Sci. Rep. 7 (2017) 45926.
[6] M. Morello, V. Landel, E. Lacassagne, K. Baranger, C. Annweiler, F. Féron, P. Millet, Mol. Neurobiol. 55 (2018) 6463–6479.
[7] P. Yamini, R.S. Ray, K. Chopra, Inflammopharmacology 26 (2018) 39–55.
[8] Z. Alrefaie, A. ’em Alhayani, Behav. Brain Res. 287 (2015) 156–162.
[9] M.R. Durk, K. Han, E.C.Y. Chow, R. Ahrens, J.T. Henderson, P.E. Fraser, K.S. Pang, J. Neurosci. 34 (2014) 7091–7101.
[10] H.A. Shirazi, J. Rasouli, B. Ciric, A. Rostami, G.-X. Zhang, Exp. Mol. Pathol. 98 (2015) 240–245.
[11] J. Brown, J.I. Bianco, J.J. McGrath, D.W. Eyles, Neurosci. Lett. 343 (2003) 139–143.
[12] P. Naveilhan, I. Neveu, D. Wion, P. Brachet, Neuroreport 7 (1996) 2171–2175.
[13] M. Goudarzvand, M. Javan, J. Mirnajafi-Zadeh, S. Mozafari, T. Tiraihi, Cell. Mol. Neurobiol. 30 (2010) 289–299.
[14] S. Wergeland, Ø. Torkildsen, K.-M. Myhr, L. Aksnes, S.J. Mørk, L. Bø, PLoS One 6 (2011) e26262.
[15] J.-F. Chabas, D. Stephan, T. Marqueste, S. Garcia, M.-N. Lavaut, C. Nguyen, R. Legre, M. Khrestchatisky, P. Decherchi, F. Feron, PLoS One 8 (2013) e65034.
[16] P.W. Landfield, L. Cadwallader-Neal, Neurobiol. Aging 19 (1998) 469–477.
[17] K. Shinpo, S. Kikuchi, H. Sasaki, Journal of Neuroscience Research 62 (2000) 374–382.
[18] W. Jang, H.-H. Park, K.-Y. Lee, Y.J. Lee, H.-T. Kim, S.-H. Koh, Mol. Neurobiol. 51 (2015) 558–570.
[19] Z. Sepehrmanesh, F. Kolahdooz, F. Abedi, N. Mazroii, A. Assarian, Z. Asemi, A. Esmaillzadeh, J. Nutr. 146 (2016) 243–248.
[20] F.E. Nashold, D.J. Miller, C.E. Hayes, J. Neuroimmunol. 103 (2000) 171–179.
[21] J.Y. Wang, J.N. Wu, T.L. Cherng, B.J. Hoffer, H.H. Chen, C.V. Borlongan, Y. Wang, Brain Res. 904 (2001) 67–75.
[22] L.D. Brewer, V. Thibault, K.C. Chen, M.C. Langub, P.W. Landfield, N.M. Porter, J. Neurosci. 21 (2001) 98–108.
[23] G. Högberg, S.A. Gustafsson, T. Hällström, T. Gustafsson, B. Klawitter, M. Petersson, Acta Paediatr. 101 (2012) 779–783.
[24] S. Fazelian, R. Amani, Z. Paknahad, S. Kheiri, L. Khajehali, Int. J. Prev. Med. 10 (2019) 17.
[25] S. Penckofer, M. Byrn, W. Adams, M.A. Emanuele, P. Mumby, J. Kouba, D.E. Wallis, J Diabetes Res 2017 (2017) 8232863.
[26] A. Eid, S. Khoja, S. AlGhamdi, H. Alsufiani, F. Alzeben, N. Alhejaili, H.O. Tayeb, F.I. Tarazi, Metab. Brain Dis. 34 (2019) 1781–1786.
[27] P.-J. Martens, C. Gysemans, A. Verstuyf, A.C. Mathieu, Nutrients 12 (2020).
[28] A.-S. Vanherwegen, C. Gysemans, C. Mathieu, Endocrinol. Metab. Clin. North Am. 46 (2017) 1061–1094.
[29] M. Barragan, M. Good, J.K. Kolls, Nutrients 7 (2015) 8127–8151.
[30] Z. Al-Jaderi, A.A. Maghazachi, Toxins 5 (2013) 1932–1947.
[31] B. Terrier, N. Derian, Y. Schoindre, W. Chaara, G. Geri, N. Zahr, K. Mariampillai, M. Rosenzwajg, W. Carpentier, L. Musset, J.-C. Piette, A. Six, D. Klatzmann, D. Saadoun, C. Patrice, N. Costedoat-Chalumeau, Arthritis Res. Ther. 14 (2012) R221.
[32] A.-L. Khoo, H.J.P.M. Koenen, L.Y.A. Chai, F.C.G.J. Sweep, M.G. Netea, A.J.A.M. van der Ven, I. Joosten, PLoS One 7 (2012) e29250.
[33] G. Bock, B. Prietl, J.K. Mader, E. Höller, M. Wolf, S. Pilz, W.B. Graninger, B.M. Obermayer-Pietsch, T.R. Pieber, Diabetes. Metab. Res. Rev. 27 (2011) 942–945.
[34] B. Prietl, G. Treiber, J.K. Mader, E. Hoeller, M. Wolf, S. Pilz, W.B. Graninger, B.M. Obermayer-Pietsch, T.R. Pieber, Eur. J. Nutr. 53 (2014) 751–759.
[35] D. Bogdanou, M. Penna-Martinez, N. Filmann, T.L. Chung, Y. Moran-Auth, J. Wehrle, C. Cappel, S. Huenecke, E. Herrmann, U. Koehl, K. Badenhoop, Diabetes. Metab. Res. Rev. 33 (2017).
[36] M. Rafiee, M. Gharagozloo, A. Ghahiri, F. Mehrabian, M.R. Maracy, S. Kouhpayeh, I.L. Pieper, A. Rezaei, Iran. J. Immunol. 12 (2015) 252–262.
[37] S. Piantoni, L. Andreoli, M. Scarsi, A. Zanola, F. Dall’Ara, C. Pizzorni, M. Cutolo, P. Airò, A. Tincani, Lupus 24 (2015) 490–498.
[38] V. Giacomet, A. Vigano, V. Manfredini, C. Cerini, G. Bedogni, S. Mora, M. Borelli, D. Trabattoni, G.V. Zuccotti, HIV Clin. Trials 14 (2013) 51–60.
[39] J.M. Scott, J.B. Kazman, J. Palmer, J.P. McClung, E. Gaffney-Stomberg, H.G. Gasier, Scand. J. Med. Sci. Sports 29 (2019) 1322–1330.
[40] C.-S. He, W.D. Fraser, J. Tang, K. Brown, S. Renwick, J. Rudland-Thomas, J. Teah, E. Tanqueray, M. Gleeson, J. Sports Sci. 34 (2016) 67–74.
[41] Y. Zeng, M. Luo, L. Pan, Y. Chen, S. Guo, D. Luo, L. Zhu, Y. Liu, L. Pan, S. Xu, R. Zhang, C. Zhang, P. Wu, L. Ge, M. Noureddin, S.J. Pandol, Y.-P. Han, Am. J. Physiol. Gastrointest. Liver Physiol. 318 (2020) G542–G553.
[42] A. De Filippis, M. Fiorentino, L. Guida, M. Annunziata, L. Nastri, A. Rizzo, Int. Immunopharmacol. 47 (2017) 106–117.
[43] K. Subramanian, P. Bergman, B. Henriques-Normark, J. Innate Immun. 9 (2017) 375–386.
[44] D. Su, Y. Nie, A. Zhu, Z. Chen, P. Wu, L. Zhang, M. Luo, Q. Sun, L. Cai, Y. Lai, Z. Xiao, Z. Duan, S. Zheng, G. Wu, R. Hu, H. Tsukamoto, A. Lugea, Z. Liu, S.J. Pandol, Y.-P. Han, Front. Physiol. 7 (2016) 498.
[45] M. Roggenbuck, D. Anderson, K.K. Barfod, M. Feelisch, S. Geldenhuys, S.J. Sørensen, C.E. Weeden, P.H. Hart, S. Gorman, Respir. Res. 17 (2016) 116.
[46] K.E. Merriman, M.F. Kweh, J.L. Powell, J.D. Lippolis, C.D. Nelson, J. Steroid Biochem. Mol. Biol. 154 (2015) 120–129.
[47] N. Lopez-Lopez, I. Gonzalez-Curiel, J. Castañeda-Delgado, A. Montoya-Rosales, B. Gandara-Jasso, J.A. Enciso-Moreno, B. Rivas-Santiago, Microbes Infect. 16 (2014) 755–761.
[48] S. Agarwal, S.N. Singh, R. Kumar, R. Sehra, Indian J. Otolaryngol. Head Neck Surg. 71 (2019) 2225–2230.
[49] R. Krysiak, K. Kowalcze, B. Okopień, Pharmacol. Rep. 71 (2019) 367–373.
[50] R. Krysiak, W. Szkróbka, B. Okopień, Pharmacol. Rep. 71 (2019) 243–247.
[51] I. Buondonno, G. Rovera, F. Sassi, M.M. Rigoni, C. Lomater, S. Parisi, R. Pellerito, G.C. Isaia, P. D’Amelio, PLoS One 12 (2017) e0178463.
[52] H. Askmark, L. Haggård, I. Nygren, A.R. Punga, Eur. J. Neurol. 19 (2012) 1554–1560.
[53] F. Baeke, T. Takiishi, H. Korf, C. Gysemans, C. Mathieu, Curr. Opin. Pharmacol. 10 (2010) 482–496.
[54] L.R.C. de Oliveira, L.A.N. Mimura, T.F. de C. Fraga-Silva, L.L.W. Ishikawa, A.A.H. Fernandes, S.F.G. Zorzella-Pezavento, A. Sartori, Front. Pharmacol. 11 (2020) 161.
[55] P.W. Lee, A. Selhorst, S.G. Lampe, Y. Liu, Y. Yang, A.E. Lovett-Racke, Front. Neurol. 11 (2020) 19.
[56] R. Verma, J.Y. Kim, Neuroimmunomodulation 23 (2016) 75–80.
[57] J.-S. Kim, S.-Y. Ryu, I. Yun, W.-J. Kim, K.-S. Lee, J.-W. Park, Y.-I. Kim, J. Clin. Neurol. 2 (2006) 252–257.
[58] E. Garcion, L. Sindji, S. Nataf, P. Brachet, F. Darcy, C.N. Montero-Menei, Acta Neuropathol. 105 (2003) 438–448.
[59] E. Garcion, S. Nataf, A. Berod, F. Darcy, P. Brachet, Brain Res. Mol. Brain Res. 45 (1997) 255–267.
[60] N. Charoenngam, A. Shirvani, T.A. Kalajian, A. Song, M.F. Holick, Anticancer Res. 40 (2020) 551–556.
[61] L. Malaguarnera, Int. Immunopharmacol. 79 (2020) 106112.
[62] N. Naderpoor, A. Mousa, L. Fernanda Gomez Arango, H.L. Barrett, M. Dekker Nitert, B. de Courten, Nutrients 11 (2019).
[63] S. Ghaly, N.O. Kaakoush, F. Lloyd, T. McGonigle, D. Mok, A. Baird, B. Klopcic, L. Gordon, S. Gorman, C. Forest, R. Bouillon, I.C. Lawrance, P.H. Hart, Sci. Rep. 8 (2018) 11511.
[64] M. Bashir, B. Prietl, M. Tauschmann, S.I. Mautner, P.K. Kump, G. Treiber, P. Wurm, G. Gorkiewicz, C. Högenauer, T.R. Pieber, Eur. J. Nutr. 55 (2016) 1479–1489.
[65] M. Kanhere, J. He, B. Chassaing, T.R. Ziegler, J.A. Alvarez, E.A. Ivie, L. Hao, J. Hanfelt, A.T. Gewirtz, V. Tangpricha, J. Clin. Endocrinol. Metab. 103 (2018) 564–574.
[66] M. Garg, P. Hendy, J.N. Ding, S. Shaw, G. Hold, A. Hart, J. Crohns. Colitis 12 (2018) 963–972.
[67] L. Wang, J.E. Manson, Y. Song, H.D. Sesso, Ann. Intern. Med. 152 (2010) 315–323.
[68] A. Zittermann, S. Frisch, H.K. Berthold, C. Götting, J. Kuhn, K. Kleesiek, P. Stehle, H. Koertke, R. Koerfer, Am. J. Clin. Nutr. 89 (2009) 1321–1327.
[69] H. Dobnig, S. Pilz, H. Scharnagl, W. Renner, U. Seelhorst, B. Wellnitz, J. Kinkeldei, B.O. Boehm, G. Weihrauch, W. Maerz, Arch. Intern. Med. 168 (2008) 1340–1349.
[70] M.D. Witham, M.A. Nadir, A.D. Struthers, J. Hypertens. 27 (2009) 1948–1954.
[71] S. Nazarian, J.V. St Peter, R.C. Boston, S.A. Jones, C.N. Mariash, Transl. Res. 158 (2011) 276–281.
[72] A.M. Borissova, T. Tankova, G. Kirilov, L. Dakovska, R. Kovacheva, Int. J. Clin. Pract. 57 (2003) 258–261.
[73] K.E. Broe, T.C. Chen, J. Weinberg, H.A. Bischoff-Ferrari, M.F. Holick, D.P. Kiel, J. Am. Geriatr. Soc. 55 (2007) 234–239.
[74] Y. Sato, J. Iwamoto, T. Kanoko, K. Satoh, Cerebrovasc. Dis. 20 (2005) 187–192.
[75] H.A. Bischoff-Ferrari, W.C. Willett, J.B. Wong, A.E. Stuck, H.B. Staehelin, E.J. Orav, A. Thoma, D.P. Kiel, J. Henschkowski, Arch. Intern. Med. 169 (2009) 551–561.
[76] J.A. Messing, R. Heuberger, J.A. Schisa, Curr. Aging Sci. 6 (2013) 220–224.
[77] M. Singla, A. Rastogi, A.N. Aggarwal, O.M. Bhat, D. Badal, A. Bhansali, J. Diabetes 9 (2017) 1100–1106.
[78] A. Sinha, K.G. Hollingsworth, S. Ball, T. Cheetham, J. Clin. Endocrinol. Metab. 98 (2013) E509–13.
[79] L. Chen, R. Yang, W. Qiao, W. Zhang, J. Chen, L. Mao, D. Goltzman, D. Miao, Aging Cell 18 (2019) e12951.
[80] S. Tao, H. Zhang, L. Xue, X. Jiang, H. Wang, B. Li, H. Tian, Z. Zhang, Environ. Toxicol. 34 (2019) 594–609.
[81] H. Zhang, L. Xue, B. Li, Z. Zhang, S. Tao, Mol. Nutr. Food Res. 63 (2019) e1801014.
[82] Z. Rao, N. Zhang, N. Xu, Y. Pan, M. Xiao, J. Wu, H. Zhou, S. Yang, Y. Chen, Front. Immunol. 8 (2017) 1308.
[83] C.-G. Zhu, Y.-X. Liu, H. Wang, B.-P. Wang, H.-Q. Qu, B.-L. Wang, M. Zhu, Endocr. J. 64 (2017) 663–673.
[84] Z. Wang, H. Zhang, X. Sun, L. Ren, Mol. Med. Rep. 14 (2016) 2389–2396.
[85] A.S. Jiménez-Osorio, S. González-Reyes, J. Pedraza-Chaverri, Clin. Chim. Acta 448 (2015) 182–192.
[86] M.J. Berridge, Biochem. Soc. Trans. 43 (2015) 349–358.
[87] S. Christakos, P. Dhawan, A. Verstuyf, L. Verlinden, G. Carmeliet, Physiol. Rev. 96 (2016) 365–408.
[88] R.P. Heaney, M.S. Dowell, C.A. Hale, A. Bendich, J. Am. Coll. Nutr. 22 (2003) 142–146.
[89] P.M. Kidd, Altern. Med. Rev. 15 (2010) 199–222.