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VINEATROL®20 GRAPEVINE EXTRACT BENEFITS

KEY BENEFITS OF VINEATROL®20

      • Supports mood

      • Supports antioxidant defenses

      • Supports healthy aging

      • Supports cognitive function

ABOUT VINEATROL®20

Viteatrol® 20 is a grapevine shoot extract that contains resveratrol monomers and oligomers.

 

Among the most important functions of resveratrol are calorie restriction mimetic (supporting healthy aging), and metabolic, cardiovascular, immune, and cognitive support.

 

Researchers have studied thousands of resveratrol derivatives in pre-clinical and clinical trials.

 

There are a number of resveratrol derivatives that are being studied, some of which might have structure and function advantages over trans-resveratrol that make them more potent for certain functions and tend to be complementary to each other.

 

Essentially, the grape plant's resveratrol derivatives are complementary to each other. Research has shown that Vineatrol® is a more potent sirtuin 1 (Sirt-1) activator than resveratrol dimers and that it is a more potent antioxidant than resveratrol alone.

 

However, what exactly are monomers and oligomers of resveratrol? Resveratrol monomers are molecules that can bond to other identical molecules, so trans-resveratrol is an example of a resveratrol monomer.

 

Trans-ε-viniferin is a resveratrol dimer, which is two identical resveratrol molecules bonded together into a monomer: Imagine it as two resveratrol molecules.

As many as eight resveratrol molecules can couple together in the resveratrol oligomer family.

 

Vineatrol®20 has the advantage of standardized content that ensures that at least 20% of these resveratrols are present.

VINEATROL®20 - RESVERATROL FULL BENEFITS

Brain function

 

  • Supports cerebral blood flow [1–4]

  • Supports neural stem cell functions [5,6]

  • Supports neurogenesis [5–7]

  • Supports brain-derived neurotrophic factor (BDNF) [7–18]

  • Supports HPA axis signaling [13,18]

  • Supports neuroprotective functions [10,18–21]

  • Supports executive function [2,22]

  • Supports learning and memory (animals) [14,15,17,23]

 

Cardiovascular function

 

  • Supports healthy vascular function [24–27]

  • Supports cardiac function [28]

 

Exercise performance

 

  • Supports endurance performance [29]

  • Supports muscle structure and function [30,31]

  • Supports glucose uptake in muscles [28]

 

Metabolic Function

 

  • Supports healthy insulin sensitivity [26,29,32–36]

  • Supports healthy lipid levels [29,32,37]

  • Supports thermogenesis [29]

  • Supports adiponectin levels [37]

 

Mitochondrial structure and function

 

  • Supports peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) [29,30,32–34,37–39]

  • Supports nuclear transcriptional factors of mitochondrial biogenesis (nuclear respiratory factor-1 [NRF1], NRF2,

  • mitochondrial transcription factor A [TFAM]) [29,30,39,40]

  • Supports mitochondrial size and number [29,33]

  • Supports inner mitochondrial membrane folding (cristae) [29]

  • Supports mitochondrial DNA (mtDNA) [29,30,34]

  • Supports mitochondrial membrane potential [30]

  • Supports citrate synthase [29,32]

  • Supports ATP production [30,39]

  • Supports NAD+ pool [30,34,41]

  • Supports components of the electron transport chain - complex I-V [30]

  • Supports β-oxidation [29,37,41,42]

 

Signaling pathways

 

  • Supports AMPK signaling [30,32–35,37,39,41,43]

  • Supports liver kinase B1 (LKB1) signaling [30,39]

  • Supports peroxisome proliferator-activated receptor alpha (PPARα) [29]

  • Supports peroxisome proliferator-activated receptor gamma (PPARγ) [37]

  • Supports estrogen-related receptor alpha (ERRα) [29,34]

  • Supports forkhead transcription factor O 1 (FOXO1) [37]

  • Downregulates phosphodiesterase (PDE) 1 and 4 and supports adenylate cyclase/cAMP levels [41,44]

 

Antioxidant defenses

 

  • Supports antioxidant activity [21,34,36,37,40,41,45,46]

  • Supports antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]) [24,25]

  • Downregulates pro-oxidant enzymes (NADPH oxidase) [24,25]

 

Gut microbiota

 

  • Supports healthy gut microbiota [47–53]

 

Healthy aging and longevity

 

  • Supports stem cells [54–66]

  • Supports telomerase activity [54–56,67,68]

  • Supports anti-senescence functions [55,56,61,68]

  • Activates SIRT1 [30,32,37,38,40,43,69,70]

  • Supports mitochondrial uncoupling proteins UCP1, UCP2, and UCP3 [29,34]

  • Supports Klotho [40,70]

  • Supports mTOR signaling [33]

  • Delays age-related physiological changes [28]

  • Extends lifespan (mice on high-calorie diet, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae) [27,33,69,71,72]

 

Circadian rhythms

 

  • Supports circadian rhythms [73–76]

  • Supports clock gene expression [73,76]

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REFERENCES

[1] D.O. Kennedy, E.L. Wightman, J.L. Reay, G. Lietz, E.J. Okello, A. Wilde, C.F. Haskell, Am. J. Clin. Nutr. 91 (2010) 1590–1597.

[2] R.H.X. Wong, D. Raederstorff, P.R.C. Howe, Nutrients 8 (2016).

[3] E.L. Wightman, C.F. Haskell-Ramsay, J.L. Reay, G. Williamson, T. Dew, W. Zhang, D.O. Kennedy, Br. J. Nutr. 114 (2015) 1427–1437.

[4] H.M. Evans, P.R.C. Howe, R.H.X. Wong, Nutrients 9 (2017).

[5] L. Xu, Y. Yang, L. Gao, J. Zhao, Y. Cai, J. Huang, S. Jing, X. Bao, Y. Wang, J. Gao, H. Xu, X. Fan, Biochim. Biophys. Acta 1852 (2015) 1298–1310.

[6] N.B. Bottari, M.R.C. Schetinger, M.M. Pillat, T.V. Palma, H. Ulrich, M.S. Alves, V.M. Morsch, C. Melazzo, L.D. de Barros, J.L. Garcia, A.S. Da Silva, Mol. Neurobiol. 56 (2019) 2328–2338.

[7] S. Madhyastha, S. Sekhar, G. Rao, Int. J. Dev. Neurosci. 31 (2013) 580–585.

[8] M. Wiciński, M. Socha, M. Walczak, E. Wódkiewicz, B. Malinowski, S. Rewerski, K. Górski, K. Pawlak-Osińska, Nutrients 10 (2018).

[9] M. Rahvar, M. Nikseresht, S.M. Shafiee, F. Naghibalhossaini, M. Rasti, M.R. Panjehshahin, A.A. Owji, Neurochem. Res. 36 (2011) 761–765.

[10] L. Ge, L. Liu, H. Liu, S. Liu, H. Xue, X. Wang, L. Yuan, Z. Wang, D. Liu, Eur. J. Pharmacol. 768 (2015) 49–57.

[11] G. Li, G. Wang, J. Shi, X. Xie, N. Fei, L. Chen, N. Liu, M. Yang, J. Pan, W. Huang, Y. Xu, Neuropharmacology 133 (2018) 181–188.

[12] X.-H. Yang, S.-Q. Song, Y. Xu, Neuropsychiatr. Dis. Treat. 13 (2017) 2727–2736.

[13] S.H. Ali, R.M. Madhana, A. K V., E.R. Kasala, L.N. Bodduluru, S. Pitta, J.R. Mahareddy, M. Lahkar, Steroids 101 (2015) 37–42.

[14] J.-F. Ge, Y.-Y. Xu, N. Li, Y. Zhang, G.-L. Qiu, C.-H. Chu, C.-Y. Wang, G. Qin, F.-H. Chen, Endocrine Journal 62 (2015) 927–938.

[15] Y.-N. Zhao, W.-F. Li, F. Li, Z. Zhang, Y.-D. Dai, A.-L. Xu, C. Qi, J.-M. Gao, J. Gao, Biochem. Biophys. Res. Commun. 435 (2013) 597–602.

[16] J. Song, S.Y. Cheon, W. Jung, W.T. Lee, J.E. Lee, Int. J. Mol. Sci. 15 (2014) 15512–15529.

[17] J. Shen, L. Xu, C. Qu, H. Sun, J. Zhang, Behav. Brain Res. 349 (2018) 1–7.

[18] C. Pang, L. Cao, F. Wu, L. Wang, G. Wang, Y. Yu, M. Zhang, L. Chen, W. Wang, W. Lv, L. Chen, J. Zhu, J. Pan, H. Zhang, Y. Xu, L. Ding, Neuropharmacology 97 (2015) 447–456.

[19] G. Wang, L. Chen, X. Pan, J. Chen, L. Wang, W. Wang, R. Cheng, F. Wu, X. Feng, Y. Yu, H.-T. Zhang, J.M. O’Donnell, Y. Xu, Oncotarget 7 (2016).

[20] Q. Zhang, X. Wang, X. Bai, Y. Xie, T. Zhang, S. Bo, X. Chen, Mol. Med. Rep. 16 (2017) 2095–2100.

[21] R. Moldzio, K. Radad, C. Krewenka, B. Kranner, J.C. Duvigneau, W.-D. Rausch, J. Neural Transm. 120 (2013) 1271–1280.

[22] S.D. Anton, N. Ebner, J.M. Dzierzewski, Z.Z. Zlatar, M.J. Gurka, V.M. Dotson, J. Kirton, R.T. Mankowski, M. Marsiske, T.M. Manini, J. Altern. Complement. Med. 24 (2018) 725–732.

[23] Y. Yazir, T. Utkan, N. Gacar, F. Aricioglu, Physiol. Behav. 138 (2015) 297–304.

[24] G. Spanier, H. Xu, N. Xia, S. Tobias, S. Deng, L. Wojnowski, U. Forstermann, H. Li, J. Physiol. Pharmacol. 60 Suppl 4 (2009) 111–116.

[25] N. Xia, A. Daiber, A. Habermeier, E.I. Closs, T. Thum, G. Spanier, Q. Lu, M. Oelze, M. Torzewski, K.J. Lackner, T. Münzel, U. Förstermann, H. Li, J. Pharmacol. Exp. Ther. 335 (2010) 149–154.

[26] J.P. Crandall, V. Oram, G. Trandafirescu, M. Reid, P. Kishore, M. Hawkins, H.W. Cohen, N. Barzilai, J. Gerontol. A Biol. Sci. Med. Sci. 67 (2012) 1307–1312.

[27] K.J. Pearson, J.A. Baur, K.N. Lewis, L. Peshkin, N.L. Price, N. Labinskyy, W.R. Swindell, D. Kamara, R.K. Minor, E. Perez, H.A. Jamieson, Y. Zhang, S.R. Dunn, K. Sharma, N. Pleshko, L.A. Woollett, A. Csiszar, Y. Ikeno, D. Le Couteur, P.J. Elliott, K.G. Becker, P. Navas, D.K. Ingram, N.S. Wolf, Z. Ungvari, D.A. Sinclair, R. de Cabo, Cell Metab. 8 (2008) 157–168.

[28] J.L. Barger, T. Kayo, J.M. Vann, E.B. Arias, J. Wang, T.A. Hacker, Y. Wang, D. Raederstorff, J.D. Morrow, C. Leeuwenburgh, D.B. Allison, K.W. Saupe, G.D. Cartee, R. Weindruch, T.A. Prolla, PLoS One 3 (2008) e2264.

[29] M. Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, B. Geny, M. Laakso, P. Puigserver, J. Auwerx, Cell 127 (2006) 1109–1122.

[30] N.L. Price, A.P. Gomes, A.J.Y. Ling, F.V. Duarte, A. Martin-Montalvo, B.J. North, B. Agarwal, L. Ye, G. Ramadori, J.S. Teodoro, B.P. Hubbard, A.T. Varela, J.G. Davis, B. Varamini, A. Hafner, R. Moaddel, A.P. Rolo, R. Coppari, C.M. Palmeira, R. de Cabo, J.A. Baur, D.A. Sinclair, Cell Metab. 15 (2012) 675–690.

[31] J.-P.K. Hyatt, L. Nguyen, A.E. Hall, A.M. Huber, J.C. Kocan, J.A. Mattison, R. de Cabo, J.R. LaRocque, R.J. Talmadge, Front. Physiol. 7 (2016) 77.

[32] S. Timmers, E. Konings, L. Bilet, R.H. Houtkooper, T. van de Weijer, G.H. Goossens, J. Hoeks, S. van der Krieken, D. Ryu, S. Kersten, E. Moonen-Kornips, M.K.C. Hesselink, I. Kunz, V.B. Schrauwen-Hinderling, E. Blaak, J. Auwerx, P. Schrauwen, Cell Metab. 14 (2011) 612–622.

[33] J.A. Baur, K.J. Pearson, N.L. Price, H.A. Jamieson, C. Lerin, A. Kalra, V.V. Prabhu, J.S. Allard, G. Lopez-Lluch, K. Lewis, P.J. Pistell, S. Poosala, K.G. Becker, O. Boss, D. Gwinn, M. Wang, S. Ramaswamy, K.W. Fishbein, R.G. Spencer, E.G. Lakatta, D. Le Couteur, R.J. Shaw, P. Navas, P. Puigserver, D.K. Ingram, R. de Cabo, D.A. Sinclair, Nature 444 (2006) 337–342.

[34] J.-H. Um, S.-J. Park, H. Kang, S. Yang, M. Foretz, M.W. McBurney, M.K. Kim, B. Viollet, J.H. Chung, Diabetes 59 (2010) 554–563.

[35] C.E. Park, M.-J. Kim, J.H. Lee, B.-I. Min, H. Bae, W. Choe, S.-S. Kim, J. Ha, Exp. Mol. Med. 39 (2007) 222–229.

[36] P. Brasnyó, G.A. Molnár, M. Mohás, L. Markó, B. Laczy, J. Cseh, E. Mikolás, I.A. Szijártó, A. Mérei, R. Halmai, L.G. Mészáros, B. Sümegi, I. Wittmann, Br. J. Nutr. 106 (2011) 383–389.

[37] J.M. Ajmo, X. Liang, C.Q. Rogers, B. Pennock, M. You, Am. J. Physiol. Gastrointest. Liver Physiol. 295 (2008) G833–42.

[38] T.D. Scribbans, J.K. Ma, B.A. Edgett, K.A. Vorobej, A.S. Mitchell, J.G.E. Zelt, C.A. Simpson, J. Quadrilatero, B.J. Gurd, Appl. Physiol. Nutr. Metab. 39 (2014) 1305–1313.

[39] B. Dasgupta, J. Milbrandt, Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 7217–7222.

[40] P. Zhang, Y. Li, Y. Du, G. Li, L. Wang, F. Zhou, Transplant. Proc. 48 (2016) 3378–3386.

[41] S.-J. Park, F. Ahmad, A. Philp, K. Baar, T. Williams, H. Luo, H. Ke, H. Rehmann, R. Taussig, A.L. Brown, M.K. Kim, M.A. Beaven, A.B. Burgin, V. Manganiello, J.H. Chung, Cell 148 (2012) 421–433.

[42] J. Most, S. Timmers, I. Warnke, J.W. Jocken, M. van Boekschoten, P. de Groot, I. Bendik, P. Schrauwen, G.H. Goossens, E.E. Blaak, Am. J. Clin. Nutr. 104 (2016) 215–227.

[43] K.P. Goh, H.Y. Lee, D.P. Lau, W. Supaat, Y.H. Chan, A.F.Y. Koh, Int. J. Sport Nutr. Exerc. Metab. 24 (2014) 2–13.

[44] A.M. El-Mowafy, M. Alkhalaf, Carcinogenesis 24 (2003) 869–873.

[45] Y.K. Gupta, S. Briyal, G. Chaudhary, Pharmacol. Biochem. Behav. 71 (2002) 245–249.

[46] S.S. Leonard, C. Xia, B.-H. Jiang, B. Stinefelt, H. Klandorf, G.K. Harris, X. Shi, Biochem. Biophys. Res. Commun. 309 (2003) 1017–1026.

[47] Y.-L. Tain, W.-C. Lee, K.L.H. Wu, S. Leu, J.Y.H. Chan, Mol. Nutr. Food Res. (2018) e1800066.

[48] Y. Zheng, W. Wu, G. Hu, L. Qiu, S. Meng, C. Song, L. Fan, Z. Zhao, X. Bing, J. Chen, Fish Shellfish Immunol. 77 (2018) 200–207.

[49] L. Zhao, Q. Zhang, W. Ma, F. Tian, H. Shen, M. Zhou, Food Funct. 8 (2017) 4644–4656.

[50] J.K. Bird, D. Raederstorff, P. Weber, R.E. Steinert, Adv. Nutr. 8 (2017) 839–849.

[51] A.S. Korsholm, T.N. Kjær, M.J. Ornstrup, S.B. Pedersen, Int. J. Mol. Sci. 18 (2017).

[52] M.M. Sung, T.T. Kim, E. Denou, C.-L.M. Soltys, S.M. Hamza, N.J. Byrne, G. Masson, H. Park, D.S. Wishart, K.L. Madsen, J.D. Schertzer, J.R.B. Dyck, Diabetes 66 (2017) 418–425.

[53] M. Larrosa, M.J. Yañéz-Gascón, M.V. Selma, A. González-Sarrías, S. Toti, J.J. Cerón, F. Tomás-Barberán, P. Dolara, J.C. Espín, J. Agric. Food Chem. 57 (2009) 2211–2220.

[54] V.P. Pearce, J. Sherrell, Z. Lou, L. Kopelovich, W.E. Wright, J.W. Shay, Oncogene 27 (2008) 2365–2374.

[55] L. Xia, X.X. Wang, X.S. Hu, X.G. Guo, Y.P. Shang, H.J. Chen, C.L. Zeng, F.R. Zhang, J.Z. Chen, Br. J. Pharmacol. 155 (2008) 387–394.

[56] X.-B. Wang, L. Zhu, J. Huang, Y.-G. Yin, X.-Q. Kong, Q.-F. Rong, A.-W. Shi, K.-J. Cao, Chin. Med. J. 124 (2011) 4310–4315.

[57] M.L. Balestrieri, C. Schiano, F. Felice, A. Casamassimi, A. Balestrieri, L. Milone, L. Servillo, C. Napoli, J. Biochem. 143 (2008) 179–186.

[58] L. Ling, S. Gu, Y. Cheng, Mol. Med. Rep. 15 (2017) 1188–1194.

[59] X.-H. Chen, Z.-G. Shi, H.-B. Lin, F. Wu, F. Zheng, C.-F. Wu, M.-W. Huang, Eur. Rev. Med. Pharmacol. Sci. 23 (2019) 6352–6359.

[60] H. Zhang, Z. Zhai, Y. Wang, J. Zhang, H. Wu, Y. Wang, C. Li, D. Li, L. Lu, X. Wang, J. Chang, Q. Hou, Z. Ju, D. Zhou, A. Meng, Free Radic. Biol. Med. 54 (2013) 40–50.

[61] Y.-J. Lv, Y. Yang, B.-D. Sui, C.-H. Hu, P. Zhao, L. Liao, J. Chen, L.-Q. Zhang, T.-T. Yang, S.-F. Zhang, Y. Jin, Theranostics 8 (2018) 2387–2406.

[62] H. Liu, S. Zhang, L. Zhao, Y. Zhang, Q. Li, X. Chai, Y. Zhang, Stem Cells Int. 2016 (2016) 2524092.

[63] I.I. Suvorova, A.R. Knyazeva, A.V. Petukhov, N.D. Aksenov, V.A. Pospelov, Cell Death Discov 5 (2019) 61.

[64] Y.-J. Wang, P. Zhao, B.-D. Sui, N. Liu, C.-H. Hu, J. Chen, C.-X. Zheng, A.-Q. Liu, K. Xuan, Y.-P. Pan, Y. Jin, Exp. Mol. Med. 50 (2018) 1–15.

[65] T.-S. Chen, C.-H. Kuo, C.H. Day, L.-F. Pan, R.-J. Chen, B.-C. Chen, V.V. Padma, Y.-M. Lin, C.-Y. Huang, J. Cell. Physiol. 234 (2019) 20443–20452.

[66] Z. Safaeinejad, M. Nabiuni, M. Peymani, K. Ghaedi, M.H. Nasr-Esfahani, H. Baharvand, Eur. J. Cell Biol. 96 (2017) 665–672.

[67] F. Uchiumi, T. Watanabe, S. Hasegawa, T. Hoshi, Y. Higami, S.-I. Tanuma, Curr. Aging Sci. 4 (2011) 1–7.

[68] J. Li, C.-X. Zhang, Y.-M. Liu, K.-L. Chen, G. Chen, Oncotarget 8 (2017) 65717–65729.

[69] K.T. Howitz, K.J. Bitterman, H.Y. Cohen, D.W. Lamming, S. Lavu, J.G. Wood, R.E. Zipkin, P. Chung, A. Kisielewski, L.-L. Zhang, B. Scherer, D.A. Sinclair, Nature 425 (2003) 191–196.

[70] S.-C. Hsu, S.-M. Huang, A. Chen, C.-Y. Sun, S.-H. Lin, J.-S. Chen, S.-T. Liu, Y.-J. Hsu, Int. J. Biochem. Cell Biol. 53 (2014) 361–371.

[71] T.M. Bass, D. Weinkove, K. Houthoofd, D. Gems, L. Partridge, Mech. Ageing Dev. 128 (2007) 546–552.

[72] J.G. Wood, B. Rogina, S. Lavu, K. Howitz, S.L. Helfand, M. Tatar, D. Sinclair, Nature 430 (2004) 686–689.

[73] J. Miranda, M.P. Portillo, J.A. Madrid, N. Arias, M.T. Macarulla, M. Garaulet, Br. J. Nutr. 110 (2013) 1421–1428.

[74] F. Pifferi, A. Dal-Pan, S. Languille, F. Aujard, Oxid. Med. Cell. Longev. 2013 (2013) 187301.

[75] J.R. Leheste, G. Torres, Front. Mol. Neurosci. 8 (2015) 61.

[76] L. Sun, Y. Wang, Y. Song, X.-R. Cheng, S. Xia, M.R.T. Rahman, Y. Shi, G. Le, Biochem. Biophys. Res. Commun. 458 (2015) 86–91.