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- Supports cognition
- Supports cardiac function
- Supports muscle performance
- Supports mitochondrial efficiency
Among the components of tricreatine malate are three creatines bound to one malate. Each of these molecules is essential for the efficient production of energy in cells.
Originally discovered in skeletal muscles, creatine gets its name from the Greek word kreas, meaning "meat.".
A key role is played by it in tissues like muscles and the brain, which require significant amounts of energy. It concentrates on muscles, which makes red meat, pork, lamb, poultry, and fish the best sources of food.
People who do not consume meat may not produce sufficient creatine to maintain optimal tissue status, even though they can make some creatine in the body. Therefore, vegans and vegetarians should take creatine as a dietary supplement.
Phosphocreatine (phosphagen) is used to create creatine. An important function of this system is to regenerate ATP from ADP in tissues during high energy demand. It is for this reason that creatine is described as an ATP "buffer."
Malate is a salt of malic acid, which has been first identified in apple juice, leading to its name, which comes from the Latin for apple (mālum).
As an intermediate in the citric acid cycle, malate aids in converting food into energy (ATP) and helping build-essential biomolecules. This cycle can be sped up by adding intermediates like malate (i.e., the cycle will spin faster).
Mitochondrial biogenesis
Mitochondrial structure and function
Signaling pathways
Exercise performance (ergogenic effects)
Cardiovascular function
Neuroprotective effects
Complementary ingredients
Krebs cyle (citric acid cycle) function
Mitochondrial function
Antioxidant defenses
Cellular signaling
Cardiovascular function
Longevity
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[1] J. T. Brosnan, R. P. da Silva, M. E. Brosnan, Amino Acids. 40, 1325–1331 (2011).
[2] M. E. Brosnan, J. T. Brosnan, Amino Acids. 48, 1785–1791 (2016).
[3] R. Cooper, F. Naclerio, J. Allgrove, A. Jimenez, J. Int. Soc. Sports Nutr. 9, 33 (2012).
[4] E. Barbieri et al., Oxid. Med. Cell. Longev. 2016, 5152029 (2016).
[5] L. M. Rambo et al., Amino Acids. 44, 857–868 (2013).
[6] P. Klivenyi et al., Nat. Med. 5, 347–350 (1999).
[7] L. Zhang et al., J. Agric. Food Chem. 65, 6991–6999 (2017).
[8] C. R. R. Alves et al., Amino Acids. 43, 1803–1807 (2012).
[9] J.-S. Ju, J. L. Smith, P. J. Oppelt, J. S. Fisher, Am. J. Physiol. Endocrinol. Metab. 288, E347–52 (2005).
[10] R. B. Ceddia, G. Sweeney, J. Physiol. 555, 409–421 (2004).
[11] B. Banerjee et al., Magn. Reson. Imaging. 28, 698–707 (2010).
[12] B. Gualano et al., Med. Sci. Sports Exerc. 43, 770–778 (2011).
[13] C. R. R. Alves et al., Arthritis Care Res. . 65, 1449–1459 (2013).
[14] D. G. Burke et al., Med. Sci. Sports Exerc. 35, 1946–1955 (2003).
[15] J. T. Brosnan, M. E. Brosnan, Annu. Rev. Nutr. 27, 241–261 (2007).
[16] J. S. Volek et al., Med. Sci. Sports Exerc. 31, 1147–1156 (1999).
[17] S. L. Nissen, R. L. Sharp, J. Appl. Physiol. 94, 651–659 (2003).
[18] R. B. Kreider, Mol. Cell. Biochem. 244, 89–94 (2003).
[19] L. A. Gotshalk et al., Eur. J. Appl. Physiol. 102, 223–231 (2008).
[20] L. A. Gotshalk et al., Med. Sci. Sports Exerc. 34, 537–543 (2002).
[21] J. D. Branch, Int. J. Sport Nutr. Exerc. Metab. 13, 198–226 (2003).
[22] B. Op ’t Eijnde, B. Ursø, E. A. Richter, P. L. Greenhaff, P. Hespel, Diabetes. 50, 18–23 (2001).
[23] V. Saks et al., J. Physiol. 571, 253–273 (2006).
[24] C. A. Lygate et al., Cardiovasc. Res. 96, 466–475 (2012).
[25] G. J. Brewer, T. W. Wallimann, J. Neurochem. 74, 1968–1978 (2000).
[26] B. Valastro, A. Dekundy, W. Danysz, G. Quack, Behav. Brain Res. 197, 90–96 (2009).
[27] R. T. Matthews et al., J. Neurosci. 18, 156–163 (1998).
[28] P. G. Sullivan, J. D. Geiger, M. P. Mattson, S. W. Scheff, Ann. Neurol. 48, 723–729 (2000).
[29] M. C. Rodriguez et al., Muscle Nerve. 35, 235–242 (2007).
[30] M. Evans et al., Nutr. Metab. . 14, 7 (2017).
[31] J. M. Berg, J. L. Tymoczko, G. J. Gatto, L. Stryer, Eds., Biochemistry (W.H. Freeman and Company, 8th ed., 2015).
[32] C. B. Edwards, N. Copes, A. G. Brito, J. Canfield, P. C. Bradshaw, PLoS One. 8, e58345 (2013).
[33] J.-L. Wu, Q.-P. Wu, Y.-P. Peng, J.-M. Zhang, Physiol. Res. 60, 329–336 (2011).
[34] S. Ding, Y. Yang, J. Mei, Evid. Based. Complement. Alternat. Med. 2016, 3803657 (2016).
[35] X. Zeng, J. Wu, Q. Wu, J. Zhang, Physiol. Res. 64, 71–78 (2015).
[36] J.-L. Wu et al., Physiol. Res. 57, 261–268 (2008).
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