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TINOFEND® TINOSPORA CORDIFOLIA STEM EXTRACT BENEFITS

KEY BENEFITS OF TINOSPORA CORDIFOLIA STEM EXTRACT

        • Supports exercise performance
        • Supports cognitive function
        • Supports general immune health

ABOUT TINOSPORA CORDIFOLIA STEM EXTRACT

Rasayanas are elixirs and tonics prized by the branch of Ayurvedic medicine devoted to rejuvenation and promoting mental and physical health. Tinospora cordifolia is a Rasayana.

 

India calls it Amrita, which means immortality, Guduchi, which means the one who protects the entire body, or Giloe, which means heavenly elixir[1,2].

 

Traditionally, T.cordifolia was used as a tonic to counter mental fatigue and improve thinking (Madhya Rasayana).

 

In addition to acting as an adaptogen, T.cordifolia was believed to support resilience to and recovery from stress.

 

Immunity is one of its traditional uses, especially when it comes to promoting a balanced immune system.

 

Various active compounds are present in T.cordifolia, including polysaccharides and bitter compounds[3–6].


TINOSPORA CORDIFOLIA STEM EXTRACT FULL BENEFITS

Immune function

 

  • Supports immune balance[7,8]
  • Supports immune tolerance[9,10]
  • Supports innate immunity[5,6,8,11–22]
  • Supports adaptive immunity[5,6,16,17,19,23–25]
  • Supports myeloid differentiation of immune hematopoietic stem cells[13]
  • Supports healthy neutrophil and macrophage function[4–6,8,11–15,18,20–22]
  • Supports healthy dendritic cell function[16,17,26]
  • Supports healthy natural killer cell function[19]
  • Supports healthy T cell function[6,16,17,19,25]
  • Supports healthy B cell function[5,6,19,24]
  • Supports immune signaling[10,18–20,22,23,27,28]

 

Brain function

 

  • Supports cognitive function[29–32]
  • Supports neuroprotection[33–35]
  • Modulates neuroimmune signaling[36]
  • Downregulates neural oxidative stress[33]
  • Supports healthy behavioral and cognitive responses to stress[37–40]

 

Exercise

 

  • Supports exercise performance[41]
  • Supports healthy cardiovascular response to exercise[41]
  • Supports healthy cortisol and testosterone levels[42]
  • Supports healthy muscles[43]

 

Healthy aging

 

  • Supports healthy aging mechanisms[13,20,44–47]

TINOFEND® TINOSPORA CORDIFOLIA STEM EXTRACT CAN BE FOUND IN:

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REFERENCES

[1] A. Upadhyay, K. Kumar, A. Kumar, H. Mishra, International Journal of Ayurveda Research 1 (2010) 112.
[2] N. Rawat, R. Roushan, World Journal of Pharmaceutical Research 7 (2018) 355–361.
[3] M.A. Haque, I. Jantan, S.N. Abbas Bukhari, J. Ethnopharmacol. 207 (2017) 67–85.
[4] U. Sharma, M. Bala, N. Kumar, B. Singh, R.K. Munshi, S. Bhalerao, J. Ethnopharmacol. 141 (2012) 918–926.
[5] A. Kapil, S. Sharma, J. Ethnopharmacol. 58 (1997) 89–95.
[6] I. Aranha, F. Clement, Y.P. Venkatesh, J. Ethnopharmacol. 139 (2012) 366–372.
[7] V.A. Badar, V.R. Thawani, P.T. Wakode, M.P. Shrivastava, K.J. Gharpure, L.L. Hingorani, R.M. Khiyani, J. Ethnopharmacol. 96 (2005) 445–449.
[8] M.V. Kalikar, V.R. Thawani, U.K. Varadpande, S.D. Sontakke, R.P. Singh, R.K. Khiyani, Indian J. Pharmacol. 40 (2008) 107–110.
[9] D. Gururaja, V. Hegde, J. Ayurveda Integr. Med. 10 (2019) 294–298.
[10] K.M. Sannegowda, S.H. Venkatesha, K.D. Moudgil, Int. J. Immunopathol. Pharmacol. 28 (2015) 521–531.
[11] N. Rege, R.D. Bapat, R. Koti, N.K. Desai, S. Dahanukar, Indian J. Gastroenterol. 12 (1993) 5–8.
[12] P.K. Gupta, M.G.R. Rajan, S. Kulkarni, Int. Immunopharmacol. 50 (2017) 168–177.
[13] S.M. Singh, N. Singh, P. Shrivastava, Fitoterapia 77 (2006) 1–11.
[14] M. Sengupta, G.D. Sharma, B. Chakraborty, BMC Complement. Altern. Med. 11 (2011) 102.
[15] L. Singh, S. Tyagi, M.A. Rizvi, H.C. Goel, J. Radiat. Res. 48 (2007) 305–315.
[16] V.K. Pandey, B.S. Shankar, K.B. Sainis, Int. Immunopharmacol. 14 (2012) 641–649.
[17] V.K. Pandey, P.J. Amin, B.S. Shankar, Int. Immunopharmacol. 23 (2014) 480–488.
[18] V.R. Desai, R. Ramkrishnan, G.J. Chintalwar, K.B. Sainis, Int. Immunopharmacol. 7 (2007) 1375–1386.
[19] P.K.R. Nair, S. Rodriguez, R. Ramachandran, A. Alamo, S.J. Melnick, E. Escalon, P.I. Garcia Jr, S.F. Wnuk, C. Ramachandran, Int. Immunopharmacol. 4 (2004) 1645–1659.
[20] N. Singh, S.M. Singh, P. Shrivastava, Immunopharmacol. Immunotoxicol. 26 (2004) 145–162.
[21] P. More, K. Pai, J. Ayurveda Integr. Med. 8 (2017) 88–92.
[22] P.K.R. Nair, S.J. Melnick, R. Ramachandran, E. Escalon, C. Ramachandran, Int. Immunopharmacol. 6 (2006) 1815–1824.
[23] V. Aher, A. Kumar Wahi, Iran J Pharm Res 11 (2012) 863–872.
[24] I. Aranha, Y.P. Venkatesh, J. Ayurveda Integr. Med. (2018).
[25] S.K. Latheef, K. Dhama, H.A. Samad, M.Y. Wani, M.A. Kumar, M. Palanivelu, Y.S. Malik, S.D. Singh, R. Singh, Virusdisease 28 (2017) 115–120.
[26] N. Singh, S.M. Singh, P. Shrivastava, Immunopharmacol. Immunotoxicol. 27 (2005) 1–14.
[27] P.V. Leyon, G. Kuttan, Int. Immunopharmacol. 4 (2004) 1569–1575.
[28] M. Tiwari, U.N. Dwivedi, P. Kakkar, J. Ethnopharmacol. 153 (2014) 326–337.
[29] A. Gupta, H. Raj, M.S. Karchuli, N. Upmanyu, Curr. Aging Sci. 6 (2013) 239–243.
[30] H.O. Malve, S.B. Raut, P.A. Marathe, N.N. Rege, J. Ayurveda Integr. Med. 5 (2014) 209–215.
[31] J. H., S. G., V. K., S. H., International Journal of Basic and Clinical Pharmacology (2016) 2159–2163.
[32] H.O. Malve, J. Ayurveda Integr. Med. 6 (2015) 233–240.
[33] J. Kosaraju, S. Chinni, P.D. Roy, E. Kannan, A.S. Antony, M.N.S. Kumar, Indian J. Pharmacol. 46 (2014) 176–180.
[34] A. Sharma, S. Kalotra, P. Bajaj, H. Singh, G. Kaur, Neuromolecular Med. 22 (2020) 81–99.
[35] H.D. Une, M.A. Ejaj, V.A. Tarde, Int J Pharma Res Rev 3 (2014) 28–35.
[36] H. Birla, S.N. Rai, S.S. Singh, W. Zahra, A. Rawat, N. Tiwari, R.K. Singh, A. Pathak, S.P. Singh, Neuromolecular Med. 21 (2019) 42–53.
[37] B.N.G. Jain, V.K. Jain, A. Shete, J. Adv. Pharm. Technol. Res. 1 (2010) 30–33.
[38] D. Dhingra, P.K. Goyal, Indian J. Pharm. Sci. 70 (2008) 761–767.
[39] H. Singh, T. Kaur, S. Manchanda, G. Kaur, Biogerontology 18 (2017) 601–614.
[40] R. Mishra, S. Manchanda, M. Gupta, T. Kaur, V. Saini, A. Sharma, G. Kaur, Sci. Rep. 6 (2016) 25564.
[41] B.A. Salve, R.K. Tripathi, A.U. Petare, A.A. Raut, N.N. Rege, Ayu 36 (2015) 265–270.
[42] S. Kumari, A. Mittal, R. Dabur, Steroids 114 (2016) 68–77.
[43] B. Sharma, V. Dutt, N. Kaur, A. Mittal, R. Dabur, J. Ethnopharmacol. 254 (2020) 112720.
[44] G.C. Jagetia, S.K. Rao, Biol. Pharm. Bull. 29 (2006) 460–466.
[45] A. Sharma, S.K. Saggu, R. Mishra, G. Kaur, Ann Neurosci 26 (2019) 10–20.
[46] A. Palmieri, L. Scapoli, A. Iapichino, L. Mercolini, M. Mandrone, F. Poli, A.B. Giannì, C. Baserga, M. Martinelli, Int. J. Immunopathol. Pharmacol. 33 (2019) 2058738419855567.
[47] N. Singh, S.M. Singh, Prakash, G. Singh, Immunopharmacol. Immunotoxicol. 27 (2005) 585–599.