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SULFORAPHANE

TOP BENEFITS OF SULFORAPHANE

        • Reduces inflammation in the lungs, liver, skin and digestive system [1,10,17,18,22]
          Boost heart Health [1]
        • Support cognitive functions [6]
        • Increases the level of antioxidants, such as glutathione [8]
        • Prevention of neurodevelopmental disorders like Autism Spectrum Disorder [9]
        • Protects skin from sunburn [10]
        • Exert antioxidant and anti-inflammatory effects [17]
        • Protect against carcinogens [17]
        • Stimulates cell autophagy to prevent abnormal proliferation[18]
        • Protect cells from DNA damage [23]
        • Protects against respiratory inflammation [25]

WHAT IS SULFORAPHANE?

A powerful phytochemical that belongs to the isothiocyanate family of organosulfur compounds and is derived from the Brassica family of vegetables, notably in Broccoli, Brussels sprouts, and cabbages. When a plant is damaged (such as by chewing or boiling during food preparation), the enzyme myrosinase converts glucoraphanin, a glucosinolate, into sulforaphane, allowing the two chemicals to interact and react. Glucoraphanin is notably abundant in young sprouts of broccoli and cauliflower [2].

When it comes to sulforaphane levels, steaming veggies for one to three minutes is the best way to go. Cooking the veggies below 284°F (140°C) prevents glucosinolates such as glucoraphanin from being lost [4].

 

As a result, cruciferous vegetables should not be cooked or microwaved. To get the most sulforaphane out of them, eat them raw or lightly cooked instead. In 1992, a group of scientists discovered sulforaphane as a food-derived molecule with substantial clinical potential.

 

It was found to be involved in the activation of the cytoplasmic transcription factor Nrf2, which then translocates to the nucleus and activates the Antioxidant Response Element (ARE) in hundreds of genes, which are involved in cellular defence [5]. It has no negative side effects and improves additional areas of health.

SULFORAPHANE KEY MECHANISMS

Brain

 

  • Support cognitive functions [6]
  • Slows cell death in the hippocampus [6]
  • Prevents memory dysfunction [7]
  • Increases level of antioxidants like glutathione that influences cognitive functions [8]
  • Prevention of neurodevelopmental disorder like Autism Spectrum Disorder [9]

 

Skin

 

  • Protects skin sunburn [10]
  • Enhances the healing process from inflammatory skin conditions e.g acne [11]

 

Heart

 

  • Reduce inflammation that involves narrowing of arteries [12]
  • Maintains blood pressure (the main cause of heart failure) [13]
  • Reduces oxidative stress [14]
  • Decreases cholesterol level [15]

 

Liver

 

  • Increases the antioxidant defense enzymes [16]
  • Protect against carcinogens [17]
  • Enhances liver functioning e.g clear caffeine from bloodstream faster [17]
  • Protection against exercise-induced inflammation [16]
  • Exert antioxidant and anti-inflammatory effects [17]
  • Alleviate D-galactosamine/lipopolysaccharide-induced liver injury [18]
  • Protective role against toxicity caused by certain medicines e.g aspirin [18]

 

Digestive System

 

  • Prevents LPS (lipopolysaccharides) induced injury [19]
  • Reduces inflammation [19]
  • Support antibacterial activity e.g against H.Pylori [20]
  • Normalize gut microbiota [21]

 

Bladder

 

  • Support antioxidant activity [18]
  • Protection against bladder dysfunctioning [18]

 

Bones

 

  • Support bone growth [18]
  • Increases bones strength [22]
  • Inhibits bone resorption [18]

 

Cellular Activity

 

  • Stimulates red blood cells suicidal death to prevent abnormal proliferation of cells [18].
  • Stimulates autophagy in cells. [18]
  • Protect cells from DNA damage (that lead to cancer) [23]

 

Lungs

 

  • Improve functioning [24]
  • Support antibacterial activity [24]
  • Protects against respiratory inflammation [25]

SULFORAPHANE CAN BE FOUND IN:

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REFERENCES

[1] K. MUDGE, "6 Proven Health Benefits Of Sulforaphane," 3X4 Genetics, July 2020. [Online]. Available: https://www.3x4genetics.com/blog/nutrition/6-proven-health-benefits-of-sulforaphane/. [Accessed 12 November 2021].
[2] M. I. Center, ""Isothiocyanates"," Oregon State University, Linus Pauling Institute, 2017.
[3] J. W. F. R. V. K. a. T. W. K. A. T. Dinkova-Kostova, " “KEAP1 and done? Targeting the NRF2 pathway with sulforaphane,”," Trends in Food Science & Technology, vol. 69, p. 257–269, 2017.
[4] G. F. S. B. Y. J. &. W. Q. M. Yuan, " Effects of different cooking methods on health-promoting compounds of broccoli.," Journal of Zhejiang University. Science. B,, p. 580–588, 2009.
[5] C. A. Houghton, " "Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease"," Oxidative Medicine and Cellular Longevity, p. 27, 2019.
[6] T. G. S.-A. T. S. A. R. T. R. M. P. A. P. R. L. L. V. B. B. S. A. A. v. V. E. D. G. E. A. E. A. D. P. M. W. M. V. A. Pauletti A, "Brain," vol. 7 , no. 140, pp. 1885-1899, 2017.
[7] F. H. Z. Y. X. G. T. J. Z. Y. Z. D. Z. G. X. J. Z. Z. Q. M. M. Y. Z. H. Z. Wang G, "Cell Physiol Biochem," vol. 39, no. 3, pp. 901-7., 2016; 39(3):.
[8] S. T. ·. N. L. ·. K. M. ·. S. L. ·. H. C. ·. T. T. ·. W. A. ·. C. J. ·. B. P. ·. F. J. ·. S. A.a, "Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study," Karger, vol. 3, p. 214–222, 2017.
[9] T. Y. L. M. a. F. Z. Y Sun, "Sulforaphane Protects against Brain Diseases: Roles of Cytoprotective Enzymes," Austin journal of cerebrovascular disease & stroke, , vol. 1, no. 4, p. 1054, 2017.
[10] P. M. D. J. Sikdar S, " What do we know about sulforaphane protection against photoaging?," Journal of Cosmetic Dermatology, vol. 1, no. 15, pp. 72-7., 2016.
[11] J. Schneider, "Why Sulforaphane Glucosinolate (SGS) Is The Best Antioxidant You Never Knew You Needed," mbglifestyle, 21 May 2020. [Online]. Available: https://www.mindbodygreen.com/articles/what-is-sulforaphane. [Accessed 16 November 2021].
[12] D. Coyle, "Sulforaphane: Benefits, Side Effects, and Food Sources," Healthline, 26 February 2019. [Online]. [Accessed 16 November 2021].
[13] A. B. L. W. P. L. B. H. J. J. Gamarallage V K Senanayake 1, "The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats," Pubmed, vol. 2, no. 25, pp. 229-35, 2012.
[14] B. J. B. B. d. C. A. P. S. F. H. S. P. L. S. B. I. A. A. K. N. B.-K. A. Fernandes RO, Molecular Cell Biochemistry, Vols. 1-2, no. 401, pp. 61-70.
[15] "High Blood Cholesterol, What You Need to Know .”," Nih.gov , 2005. [Online]. Available: www.nhlbi.nih.gov/files/docs/public/heart/wyntk.pdf .. [Accessed 17 Novemebr 2021].
[16] R. T. S. M. a. K. S. Ruhee, "rotective Effects of Sulforaphane on Exercise-Induced Organ Damage via Inducing Antioxidant Defense Responses," Antioxidants, p. 136, 2020.
[17] S. Murray, ""Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man."," Carcinogenesis , vol. 9, no. 22, pp. 1413-1420, 2001.
[18] J. K. K. a. S. U. Park, "Current potential health benefits of sulforaphane," EXCLI journal, vol. 15, p. 571–577., 2016.
[19] Q. W. Yu-jie Zhang, "Sulforaphane protects intestinal epithelial cells against lipopolysaccharide-induced injury by activating the AMPK/SIRT1/PGC-1ɑ pathway," Bioengineered , pp. 4349-4360, 2021.
[20] A. Yanaka, "Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress," Current pharmaceutical design, , vol. 27, no. 23, p. 4066–4075., 2017.
[21] L. H. L. L. L. S. Canxia He, "Sulforaphane Normalizes Intestinal Flora and Enhances Gut Barrier in Mice with BBN-Induced Bladder Cancer," Wiley online library, vol. 62, no. 24, 2018.
[22] M. Vivian Goldschmidt, "Confirmed By Science: Sulforaphane Is More Powerful Than Osteoporosis Drugs, And Is 100% Safe," Save institute, [Online]. Available: https://saveourbones.com/confirmed-by-science-sulforaphane-is-more-powerful-than-osteoporosis-drugs/. [Accessed 17 November 2021].
[23] "Focus on Ecogenetics," University Of Washington, [Online]. Available: https://depts.washington.edu/ceeh/downloads/Focus_on_Ecogenetics_2.pdf. [Accessed 19 Novemebr 2021].
[24] J. Fang, "Broccoli chemical cleans out diseased lungs," 16 April 2011 . [Online]. Available: https://www.zdnet.com/article/broccoli-chemical-cleans-out-diseased-lungs/. [Accessed 17 November 2021].
[25] U. o. California, "Broccoli May Help Protect Against Respiratory Conditions Like Asthma," Science daily, 4 March 2009. [Online]. Available: https://www.sciencedaily.com/releases/2009/03/090302133218.htm. [Accessed 17 November 2021].