GET 15% OFF WHEN YOU START A RECURRING ORDER! USE CODE "START" IN CHECKOUT. CANCEL ANYTIME!

SELENIUM (AS SE-METHYL-L-SELENOCYSTEINE) BENEFITS

KEY BENEFITS OF SELENIUM

        • Supports thyroid health
        • Supports general immune health

ABOUT SELENIUM

There are about 25 different selenium-containing proteins identified in humans, and selenium (Se) has been recognized as a trace mineral since 1957. As an antioxidant, selenium contributes to health in numerous ways, including immune function, thyroid function, reproductive health, and DNA synthesis[1,2].

 

The thyroid gland contains the highest concentration of selenium, while muscles, liver, and bones hold the most selenium.

 

Food sources of selenium include selenomethionine, selenocysteine, and se-methyl-L-selenocysteine (organic selenium).

 

Selenium can be found in soil as selenate and selenite (which are called inorganic forms), and plants convert them into organic forms.

 

Selenium is primarily found in Brazil nuts, which contain an average of about the recommended dietary allowance (RDA) per nut. Among the best sources of selenium are fish, meat, poultry, mushrooms, and legumes.

 

The majority of ingested selenium is converted into selenoproteins (proteins containing selenocysteine) - selenoproteins are members of the selenol class of organoselenium compounds. Selenoproteins are the cofactors for antioxidant enzymes, such as glutathione peroxidase and thioredoxin reductase, and enzymes required for thyroid hormone conversion.

 

Among the organic forms of selenium, se-methyl-L-selenocysteine (MSC) is one: Most of the selenium found in Allium (for example, garlic, leeks, onions) and Brassica (for instance, broccoli, cabbage, cauliflower) is selenium in its organic form[4,5].

 

Selenium is named for a word derived from Ancient Greek - selḗnē, meaning the moon.


SELENIUM FULL BENEFITS

Immune function

 

  • Supports general immune health[1,6–10]
  • Supports innate immunity[11–16]
  • Supports adaptive immunity[7,8,11–15,17]
  • Supports immune tolerance[18–38]
  • Supports immune signaling[39–41]   
  • Supports healthy natural killer cell function[11–16,42–44]
  • Supports healthy macrophage function[45–47]   
  • Supports healthy microglial function[48,49]
  • Supports healthy neutrophil function[50–58]
  • Supports healthy mast cell function[59–61] 
  • Supports healthy T cell function[8,11–15,17]
  • Supports healthy B cell function[8,60]

 

Thyroid function

 

  • Supports thyroid function[19–21,23–37,62]

 

Gut microbiota

 

  • Supports a healthy gut microbiota[63–65]

 

Healthy aging

 

  • Supports Healthspan (Caenorhabditis elegans)[66,67]
  • Supports mitochondrial function[68–74]
  • Supports Nrf2[75–84]
  • Supports antioxidant defenses[2]
  • Supports sirtuin activity[85]
  • Supports circadian function[85–87]

 

Complementary ingredients

 

    • Zinc in supporting immunity[10,88]
    • Zinc, vitamin C and E, and beta-carotene for cognitive function during aging[89]

SELENIUM (AS SE-METHYL-L-SELENOCYSTEINE) CAN BE FOUND IN:

Morning Momentum

Get Instant Access To A Simple, Proven System That Has Helped

THOUSANDS of People

IGNITE Their Health and Energy

to Create The Life They Deserve!

Learn More


REFERENCES

[1] J.C. Avery, P.R. Hoffmann, Nutrients 10 (2018).
[2] M.P. Rayman, Lancet 379 (2012) 1256–1268.
[3] C.D. Thomson, A. Chisholm, S.K. McLachlan, J.M. Campbell, Am. J. Clin. Nutr. 87 (2008) 379–384.
[4] M.P. Rayman, H.G. Infante, M. Sargent, Br. J. Nutr. 100 (2008) 238–253.
[5] M. Montes-Bayón, M.J.D. Molet, E.B. González, A. Sanz-Medel, Talanta 68 (2006) 1287–1293.
[6] A.J. Goldson, S.J. Fairweather-Tait, C.N. Armah, Y. Bao, M.R. Broadley, J.R. Dainty, C. Furniss, D.J. Hart, B. Teucher, R. Hurst, PLoS One 6 (2011) e14771.
[7] C.S. Broome, F. McArdle, J.A.M. Kyle, F. Andrews, N.M. Lowe, C.A. Hart, J.R. Arthur, M.J. Jackson, Am. J. Clin. Nutr. 80 (2004) 154–162.
[8] W.C. Hawkes, D.S. Kelley, P.C. Taylor, Biol. Trace Elem. Res. 81 (2001) 189–213.
[9] O.M. Guillin, C. Vindry, T. Ohlmann, L. Chavatte, Nutrients 11 (2019).
[10] M.A. Johnson, K.H. Porter, Nutr. Rev. 55 (1997) 400–404.
[11] W.C. Hawkes, D. Richter, Z. Alkan, Biol. Trace Elem. Res. 155 (2013) 201–208.
[12] L. Kiremidjian-Schumacher, M. Roy, H.I. Wishe, M.W. Cohen, G. Stotzky, Biol. Trace Elem. Res. 41 (1994) 115.
[13] W.C. Hawkes, A. Hwang, Z. Alkan, J. Trace Elem. Med. Biol. 23 (2009) 272–280.
[14] N.G. Ilbäck, J. Fohlman, G. Friman, Biol. Trace Elem. Res. 63 (1998) 51–66.
[15] H.T. Petrie, L.W. Klassen, P.S. Klassen, J.R. O’Dell, H.D. Kay, J. Leukoc. Biol. 45 (1989) 215–220.
[16] L. Kiremidjian-Schumacher, M. Roy, H.I. Wishe, M.W. Cohen, G. Stotzky, Biol. Trace Elem. Res. 52 (1996) 227–239.
[17] F.W. Hoffmann, A.C. Hashimoto, L.A. Shafer, S. Dow, M.J. Berry, P.R. Hoffmann, J. Nutr. 140 (2010) 1155–1161.
[18] M. Sahebari, Z. Rezaieyazdi, M. Khodashahi, Curr. Rheumatol. Rev. 15 (2019) 123–134.
[19] I. Pirola, M. Rotondi, A. Cristiano, F. Maffezzoni, D. Pasquali, F. Marini, F. Coperchini, M. Paganelli, P. Apostoli, L. Chiovato, A. Ferlin, C. Cappelli, Endocrinol Diabetes Nutr 67 (2020) 28–35.
[20] G. Mantovani, A.M. Isidori, C. Moretti, C. Di Dato, E. Greco, P. Ciolli, M. Bonomi, L. Petrone, A. Fumarola, G. Campagna, G. Vannucchi, S. Di Sante, C. Pozza, A. Faggiano, A. Lenzi, E. Giannetta, Endocrine 66 (2019) 542–550.
[21] R. Krysiak, K. Kowalcze, B. Okopień, J. Clin. Pharmacol. 59 (2019) 1477–1484.
[22] C. Soni, I. Sinha, M.J. Fasnacht, N.J. Olsen, Z.S.M. Rahman, R. Sinha, Autoimmunity 52 (2019) 57–68.
[23] R. Krysiak, K. Kowalcze, B. Okopień, Pharmacol. Rep. 71 (2019) 367–373.
[24] R. Krysiak, W. Szkróbka, B. Okopień, Pharmacol. Rep. 71 (2019) 243–247.
[25] W. Wang, J. Mao, J. Zhao, J. Lu, L. Yan, J. Du, Z. Lu, H. Wang, M. Xu, X. Bai, L. Zhu, C. Fan, H. Wang, H. Zhang, Z. Shan, W. Teng, Thyroid 28 (2018) 1674–1681.
[26] I. Kyrgios, S. Giza, E.P. Kotanidou, A. Kleisarchaki, V.R. Tsinopoulou, A. Papadopoulou, A.-M. Markantonatou, E. Kanellidou, A. Giannakou, A. Galli-Tsinopoulou, J. Clin. Pharm. Ther. 44 (2019) 102–108.
[27] F. Karimi, G.R. Omrani, J. Endocrinol. Invest. 42 (2019) 481–487.
[28] A. Kachouei, H. Rezvanian, M. Amini, A. Aminorroaya, E. Moradi, Adv. Biomed. Res. 7 (2018) 1.
[29] M. Nordio, S. Basciani, Eur. Rev. Med. Pharmacol. Sci. 21 (2017) 51–59.
[30] S.M. Ferrari, P. Fallahi, F. Di Bari, R. Vita, S. Benvenga, A. Antonelli, Eur. Rev. Med. Pharmacol. Sci. 21 (2017) 36–42.
[31] M. Nordio, S. Basciani, Int. J. Endocrinol. 2017 (2017) 2549491.
[32] I. Pirola, E. Gandossi, B. Agosti, A. Delbarba, C. Cappelli, Endokrynol. Pol. 67 (2016) 567–571.
[33] J. Mao, V.J. Pop, S.C. Bath, H.L. Vader, C.W.G. Redman, M.P. Rayman, Eur. J. Nutr. 55 (2016) 55–61.
[34] M. Nordio, R. Pajalich, J. Thyroid Res. 2013 (2013) 424163.
[35] O. Turker, K. Kumanlioglu, I. Karapolat, I. Dogan, J. Endocrinol. 190 (2006) 151–156.
[36] J.R. O’Dell, J.P. McGivern, H.D. Kay, L.W. Klassen, Clin. Exp. Immunol. 73 (1988) 322–327.
[37] L.-X. Sang, B. Chang, J.-F. Zhu, F.-L. Yang, Y. Li, X.-F. Jiang, D.-N. Wang, C.-L. Lu, X. Sun, World J. Gastroenterol. 23 (2017) 3850–3863.
[38] H. Xue, W. Wang, Y. Li, Z. Shan, Y. Li, X. Teng, Y. Gao, C. Fan, W. Teng, Endocr. J. 57 (2010) 595–601.
[39] J. Kim, J. Ahn, Biol. Trace Elem. Res. 157 (2014) 101–106.
[40] B. Bao, A.S. Prasad, F.W.J. Beck, J.T. Fitzgerald, D. Snell, G.W. Bao, T. Singh, L.J. Cardozo, Am. J. Clin. Nutr. 91 (2010) 1634–1641.
[41] F. Marcellini, C. Giuli, R. Papa, C. Gagliardi, G. Dedoussis, D. Monti, J. Jajte, R. Giacconi, M. Malavolta, E. Mocchegiani, Rejuvenation Res. 11 (2008) 479–483.
[42] S.M. Wood, C. Beckham1, A. Yosioka2, H. Darban3, R.R. Watson, Integr. Med. 2 (2000) 85–92.
[43] A. Dhur, P. Galan, S. Hercberg, Comp. Biochem. Physiol. C 96 (1990) 271–280.
[44] L.D. Koller, J.H. Exon, P.A. Talcott, C.A. Osborne, G.M. Henningsen, Clin. Exp. Immunol. 63 (1986) 570–576.
[45] J. Xu, Y. Gong, Y. Sun, J. Cai, Q. Liu, J. Bao, J. Yang, Z. Zhang, Biol. Trace Elem. Res. 194 (2020) 237–243.
[46] M. Aribi, W. Meziane, S. Habi, Y. Boulatika, H. Marchandin, J.-L. Aymeric, PLoS One 10 (2015) e0135515.
[47] Z. Niu, F. Liu, Q. Yan, L. Li, Arch. Anim. Nutr. 63 (2009) 56–65.
[48] Z.-H. Zhang, L. Wen, Q.-Y. Wu, C. Chen, R. Zheng, Q. Liu, J.-Z. Ni, G.-L. Song, J. Agric. Food Chem. 65 (2017) 4970–4979.
[49] L. Dalla Puppa, N.E. Savaskan, A.U. Bräuer, D. Behne, A. Kyriakopoulos, Ann. N. Y. Acad. Sci. 1096 (2007) 179–183.
[50] S. Lee, I. Takahashi, M. Matsuzaka, K. Yamai, K. Danjo, T. Kumagai, T. Umeda, K. Itai, S. Nakaji, Biol. Trace Elem. Res. 144 (2011) 396–406.
[51] J.B. Montgomery, J.J. Wichtel, M.G. Wichtel, M.A. McNiven, J.T. McClure, F. Markham, D.W. Horohov, Can. J. Vet. Res. 76 (2012) 281–291.
[52] E.S. Aziz, P.H. Klesius, J.C. Frandsen, Am. J. Vet. Res. 45 (1984) 1715–1718.
[53] S.A. Köse, M. Nazıroğlu, Biol. Trace Elem. Res. 158 (2014) 136–142.
[54] E. Greenman, M.J. Phillipich, C.J. Meyer, L.J. Charamella, N.V. Dimitrov, Anticancer Res. 8 (1988) 825–828.
[55] A.E. Ibeagha, E.M. Ibeagha-Awemu, J. Mehrzad, B. Baurhoo, P. Kgwatalala, X. Zhao, Animal 3 (2009) 1037–1043.
[56] W. Mei, Z.M. Dong, B.L. Liao, H.B. Xu, Biol. Trace Elem. Res. 28 (1991) 11–19.
[57] K.C. Rocha, M.L.D.S. Vieira, R.L. Beltrame, J. Cartum, S.I.P.M. do N. Alves, L.A. Azzalis, V.B.C. Junqueira, E.C. Pereira, F.L.A. Fonseca, J. Med. Food 19 (2016) 560–568.
[58] R. Kukreja, A. Khan, Indian J. Biochem. Biophys. 31 (1994) 427–429.
[59] R. Safaralizadeh, M. Nourizadeh, A. Zare, G.A. Kardar, Z. Pourpak, Biol. Trace Elem. Res. 154 (2013) 299–303.
[60] F. Gazdik, M. Horvathova, K. Gazdikova, E. Jahnova, Bratisl. Lek. Listy 103 (2002) 17–21.
[61] T. Arakawa, H. Okubo, M. Mae, T. Okuno, H. Ogino, H. Ueno, Biol. Pharm. Bull. 42 (2019) 1179–1184.
[62] K.H. Winther, S.J. Bonnema, F. Cold, B. Debrabant, M. Nybo, S. Cold, L. Hegedüs, Eur. J. Endocrinol. 172 (2015) 657–667.
[63] K. Takahashi, N. Suzuki, Y. Ogra, Food Chem. 319 (2020) 126537.
[64] Y. Liu, J. Ji, W. Zhang, Y. Suo, J. Zhao, X. Lin, L. Cui, B. Li, H. Hu, C. Chen, Y.-F. Li, Ecotoxicol. Environ. Saf. 185 (2019) 109720.
[65] M.V. Kasaikina, M.A. Kravtsova, B.C. Lee, J. Seravalli, D.A. Peterson, J. Walter, R. Legge, A.K. Benson, D.L. Hatfield, V.N. Gladyshev, FASEB J. 25 (2011) 2492–2499.
[66] J.-S. Kim, S.-H. Kim, S.-K. Park, Clinics 72 (2017) 491–498.
[67] S.-H. Kim, B.-K. Kim, S.-K. Park, Mol. Med. Rep. 18 (2018) 5389–5398.
[68] Y. Farbood, A. Sarkaki, M. Mahdavinia, A. Ghadiri, A. Teimoori, F. Seif, M.A. Dehghani, S.P. Navabi, Neurotox. Res. 38 (2020) 398–407.
[69] O.L. Adebayo, G.A. Adenuga, R. Sandhir, Life Sci. 152 (2016) 145–155.
[70] M.L. Gheorghiu, C. Badiu, Hormones 19 (2020) 25–30.
[71] S.H. White, S. Wohlgemuth, C. Li, L.K. Warren, J. Anim. Sci. 95 (2017) 4078–4084.
[72] S.L. Mehta, S. Kumari, N. Mendelev, P.A. Li, BMC Neurosci. 13 (2012) 79.
[73] X. Peng, H. Cui, J. Yuan, W. Cui, J. Fang, Z. Zuo, J. Deng, K. Pan, Y. Zhou, W. Lai, Biol. Trace Elem. Res. 144 (2011) 688–694.
[74] A.J. Zamora, F. Tessier, P. Marconnet, I. Margaritis, J.F. Marini, Eur. J. Appl. Physiol. Occup. Physiol. 71 (1995) 505–511.
[75] D. Bartolini, K.D. Tew, R. Marinelli, F. Galli, G.Y. Wang, Biofactors 46 (2020) 239–245.
[76] R. Brigelius-Flohé, A.P. Kipp, Methods Enzymol. 527 (2013) 65–86.
[77] C. Zhang, J. Lin, J. Ge, L.-L. Wang, N. Li, X.-T. Sun, H.-B. Cao, J.-L. Li, Toxicol. In Vitro 44 (2017) 349–356.
[78] L. Liu, C. Wu, D. Chen, B. Yu, Z. Huang, Y. Luo, P. Zheng, X. Mao, J. Yu, J. Luo, H. Yan, J. He, Oxid. Med. Cell. Longev. 2020 (2020) 5490743.
[79] R. Tindell, S.B. Wall, Q. Li, R. Li, K. Dunigan, R. Wood, T.E. Tipple, Redox Biol 19 (2018) 331–338.
[80] Y. Zakharia, A. Bhattacharya, Y.M. Rustum, Oncotarget 9 (2018) 10765–10783.
[81] K. Li, Z. Cao, Y. Guo, C. Tong, S. Yang, M. Long, P. Li, J. He, Oxid. Med. Cell. Longev. 2020 (2020) 4048706.
[82] P. Li, K. Li, C. Zou, C. Tong, L. Sun, Z. Cao, S. Yang, Q. Lyu, Toxins 12 (2020).
[83] M. Schwarz, K. Lossow, J.F. Kopp, T. Schwerdtle, A.P. Kipp, Nutrients 11 (2019).
[84] E. Reszka, E. Wieczorek, E. Jablonska, B. Janasik, W. Fendler, W. Wasowicz, J. Trace Elem. Med. Biol. 30 (2015) 102–106.
[85] M. Fang, W.-R. Guo, Y. Park, H.-G. Kang, H. Zarbl, Oncotarget 6 (2015) 42879–42891.
[86] M.Z. Fang, X. Zhang, H. Zarbl, Cancer Prev. Res. 3 (2010) 640–652.
[87] X. Zhang, H. Zarbl, Cancer Prev. Res. 1 (2008) 119–127.
[88] F. Girodon, P. Galan, A.-L. Monget, M.-C. Boutron-Ruault, P. Brunet-Lecomte, P. Preziosi, J. Arnaud, J.-C. Manuguerra, S. Hercberg, Arch. Intern. Med. 159 (1999) 748–754.
[89] E. Kesse-Guyot, L. Fezeu, C. Jeandel, M. Ferry, V. Andreeva, H. Amieva, S. Hercberg, P. Galan, Am. J. Clin. Nutr. 94 (2011) 892–899.