• Supports resistance to stress

      • Supports cognitive function
      • Supports endurance capacity

      • Supports sleep

      • Supports mood


Schisandra Chinensis produces berries as its fruits. In Traditional Chinese Medicine, they are one of the 50 fundamental herbs, and they have traditionally been used in Japan, Korea, and the far east regions of the Russian empire.


The berries are known as five-flavor fruits because all five basic flavors can be found in them: salty, sweet, sour, pungent (spicy), and bitter.


The fruits of S.chinensis are known for their adaptogenic effects, stimulating mental and physical performance, mood, sleep, sight, and immunity.


Russian scientists studied the berries and seeds in both animals and humans from 1940-1960 due to its traditional uses, including countering exhaustion and supporting night vision.


Adaptogens gained recognition as a result of this research in the former USSR in the early 1960s and have since been extensively studied in Russian and English language journals.


In S.Chinensis berries, the primary active compounds are schisandra lignans. Lignans are members of the non-flavonoid polyphenol family that interact with gut microbiota (i.e., gut-brain axis) [1].




  • Supports endurance and working capacity [1]

  • Supports resistance to stress [1–8]

  • Supports sleep [1]

  • Supports a calm mood [1,9]

  • Supports healthy behavioral responses to stress [3,4,7]



Brain function


  • Supports mental performance [1]

  • Supports vision [1]

  • Supports learning and memory [7,10–13]

  • Supports GABAergic neurotransmission [3,14,15]

  • Supports GABA-Glutamate levels [10,11,15,16]

  • Supports acetylcholine signaling [10,11,13]

  • Supports serotonin signaling [9–11,16]

  • Supports adrenergic signaling [9–11,16]

  • Supports dopamine signaling [9–11,16]

  • Supports sleep mechanisms [14,15,17,18]

  • Downregulates acetylcholinesterase (AChE) activity [10,13]

  • Supports brain-derived neurotrophic factor (BDNF) [4,7]

  • Modulates glycogen synthase kinase 3β (GSK3β) activity [7,10]

  • Supports neuroprotective functions [10–13,19,20]

  • Supports brain mitochondrial function [21]

  • Supports antioxidant defenses [10,19,21,22]

  • Supports phase II detoxifying/antioxidant enzymes [22]


Gut microbiota


  • Supports the composition of the gut microbiota [23,24]

  • Supports gut microbial metabolism [24]

  • Supports gut immune responses [24]


Immune System


  • Supports innate immunity [25–27]

  • Supports immune function during some forms of stress [2,28–30]

  • Supports immunomodulation (i.e., balance of immune function) [31–33]


Healthy aging and longevity


  • Supports mitochondrial function [19,21,34]

  • Supports antioxidant defenses [21,34]

  • Supports HSP70 chaperone [34]

  • Supports autophagy [35]

  • Supports healthy muscle and bone with aging [36,37]


Complementary ingredients


  • Sesamin (from sesame seeds)—another lignan—to support liver health [38] and blood fluidity [39]

  • Other adaptogens (e.g., Rhodiola, Siberian Ginseng) as a nootropic and immune support [40,41]


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[1]A. Panossian, G. Wikman, J. Ethnopharmacol. 118 (2008) 183–212.

[2]J. Li, J. Wang, J.-Q. Shao, H. Du, Y.-T. Wang, L. Peng, Chin. J. Integr. Med. 21 (2015) 43–48.

[3]T. Yan, M. Xu, B. Wu, Z. Liao, Z. Liu, X. Zhao, K. Bi, Y. Jia, Food Funct. 7 (2016) 2811–2819.

[4]T. Yan, M. Xu, S. Wan, M. Wang, B. Wu, F. Xiao, K. Bi, Y. Jia, Psychiatry Res. 243 (2016) 135–142.

[5]Sun L.-J., Wang G.-H., Wu B., Wang J., Wang Q., Hu L.-P., Shao J.-Q., Wang Y.-T., Li J., Gu P., Lu B., Zhonghua Nan Ke Xue 15 (2009) 126–129.

[6]N. Xia, J. Li, H. Wang, J. Wang, Y. Wang, Exp. Ther. Med. 11 (2016) 353–359.

[7]T. Yan, B. He, S. Wan, M. Xu, H. Yang, F. Xiao, K. Bi, Y. Jia, Sci. Rep. 7 (2017) 6903.

[8]Xia P., Sun L.-J., Wang J., Zhonghua Nan Ke Xue 17 (2011) 472–476.

[9]W.-W. Chen, R.-R. He, Y.-F. Li, S.-B. Li, B. Tsoi, H. Kurihara, Phytomedicine 18 (2011) 1144–1147.

[10]Y. Liu, Z. Liu, M. Wei, M. Hu, K. Yue, R. Bi, S. Zhai, Z. Pi, F. Song, Z. Liu, Food Funct. 10 (2019) 432–447.

[11]B.-B. Wei, M.-Y. Liu, Z.-X. Chen, M.-J. Wei, Acta Pharmacol. Sin. 39 (2018) 616–625.

[12]N. Egashira, K. Kurauchi, K. Iwasaki, K. Mishima, K. Orito, R. Oishi, M. Fujiwara, Phytother. Res. 22 (2008) 49–52.

[13]V.V. Giridharan, R.A. Thandavarayan, S. Sato, K.M. Ko, T. Konishi, Free Radic. Res. 45 (2011) 950–958.

[14]C. Zhang, X. Mao, X. Zhao, Z. Liu, B. Liu, H. Li, K. Bi, Y. Jia, Fitoterapia 96 (2014) 123–130.

[15]N. Li, J. Liu, M. Wang, Z. Yu, K. Zhu, J. Gao, C. Wang, J. Sun, J. Chen, H. Li, Biomed. Pharmacother. 103 (2018) 509–516.

[16]B. Wei, Q. Li, R. Fan, D. Su, X. Chen, Y. Jia, K. Bi, J. Pharm. Biomed. Anal. 88 (2014) 416–422.

[17]H. Zhu, L. Zhang, G. Wang, Z. He, Y. Zhao, Y. Xu, Y. Gao, L. Zhang, J. Food Drug Anal. 24 (2016) 831–838.

[18]F. Huang, Y. Xiong, L. Xu, S. Ma, C. Dou, J. Ethnopharmacol. 110 (2007) 471–475.

[19]N. Chen, P.Y. Chiu, K.M. Ko, Biol. Pharm. Bull. 31 (2008) 1387–1391.

[20]C.-L. Li, Y.-H. Tsuang, T.-H. Tsai, Nutrients 11 (2019).

[21]K.M. Ko, N. Chen, H.Y. Leung, E.P.K. Leong, M.K.T. Poon, P.Y. Chiu, Biofactors 34 (2008) 331–342.

[22]S.Y. Park, S.J. Park, T.G. Park, S. Rajasekar, S.-J. Lee, Y.-W. Choi, Int. Immunopharmacol. 17 (2013) 415–426.

[23]M.-Y. Song, J.-H. Wang, T. Eom, H. Kim, Nutr. Res. 35 (2015) 655–663.

[24]Y. Qi, L. Chen, K. Gao, Z. Shao, X. Huo, M. Hua, S. Liu, Y. Sun, S. Li, Int. J. Biol. Macromol. 124 (2019) 627–634.

[25]M. Kortesoja, E. Karhu, E.S. Olafsdottir, J. Freysdottir, L. Hanski, Free Radic. Biol. Med. 131 (2019) 309–317.

[26]T. Zhao, Y. Feng, J. Li, R. Mao, Y. Zou, W. Feng, D. Zheng, W. Wang, Y. Chen, L. Yang, X. Wu, Int. J. Biol. Macromol. 65 (2014) 33–40.

[27]T. Zhao, G. Mao, R. Mao, Y. Zou, D. Zheng, W. Feng, Y. Ren, W. Wang, W. Zheng, J. Song, Y. Chen, L. Yang, X. Wu, Food Chem. Toxicol. 55 (2013) 609–616.

[28]L.-M. Zhao, Y.-L. Jia, M. Ma, Y.-Q. Duan, L.-H. Liu, Int. J. Biol. Macromol. 76 (2015) 63–69.

[29]J. Yu, L. Cong, C. Wang, H. Li, C. Zhang, X. Guan, P. Liu, Y. Xie, J. Chen, J. Sun, Exp. Ther. Med. 15 (2018) 4755–4762.

[30]S.-H. Tang, R.-R. He, T. Huang, C.-Z. Wang, Y.-F. Cao, Y. Zhang, H. Kurihara, J. Ethnopharmacol. 134 (2011) 141–146.

[31]Y.H. Kang, H.M. Shin, Immunopharmacol. Immunotoxicol. 34 (2012) 292–298.

[32]H. Kim, Y.-T. Ahn, Y.S. Kim, S.I. Cho, W.G. An, Pharmacogn. Mag. 10 (2014) S80–5.

[33]A.Y.S. Yip, W.T.Y. Loo, L.W.C. Chow, Biomed. Pharmacother. 61 (2007) 588–590.

[34]P.Y. Chiu, H.Y. Leung, M.K.T. Poon, K.M. Ko, Biogerontology 7 (2006) 199–210.

[35]Y. Lu, W.-J. Wang, Y.-Z. Song, Z.-Q. Liang, Pharm. Biol. 52 (2014) 1302–1307.

[36]K.-Y. Kim, S.-K. Ku, K.-W. Lee, C.-H. Song, W.G. An, J. Ethnopharmacol. 212 (2018) 175–187.

[37]J.-S. Kim, J.S. Takanche, J.-E. Kim, S.-H. Jeong, S.-H. Han, H.-K. Yi, Phytother. Res. 33 (2019) 1865–1877.

[38]H.-F. Chiu, T.-Y. Chen, Y.-T. Tzeng, C.-K. Wang, Phytother. Res. 27 (2013) 368–373.

[39]D. Tsi, A. Tan, Bioinformation 2 (2008) 249–252.

[40]G. Aslanyan, E. Amroyan, E. Gabrielyan, M. Nylander, G. Wikman, A. Panossian, Phytomedicine 17 (2010) 494–499.

[41]N. Kormosh, K. Laktionov, M. Antoshechkina, Phytother. Res. 20 (2006) 424–425.