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NIACINAMIDE (VITAMIN B3) BENEFITS

KEY BENEFITS OF NIACINAMIDE

      • Supports healthy aging and longevity
      • Supports neuroprotection
      • Supports antioxidant defenses
      • Supports energy metabolism

ABOUT NIACINAMIDE

The water-soluble vitamin Niacinamide (vitamin B3) is part of the B complex, which plays an important role in cell metabolism and energy production.
 
The B3 vitamin was discovered as the third of the B complex.
 
Because of its ability to prevent pellagra, the vitamin B3 deficiency disease, it is included in the World Health Organization's List of Essential Medicines.
 
Niacinamide does not produce the flushing effect of niacin (nicotinic acid), the vitamin B3 form.
 
The composition of compounds with niacin activity is determined by their ability to contribute nicotinamide (i.e., niacinamide) units to NAD.
 
Every cell in our body contains NAD. This enzyme is needed for three functions: (1) to make cellular energy (ATP), (2) to protect cells from damage, and (3) to activate processes that work to keep the body healthy as it ages.
 
According to recent studies, levels of certain NAD metabolites (NAD+ for example) decline significantly as we age. Having fewer NAD+ cells leaves us at a higher risk for unhealthy aging since they can't perform at their best without adequate amounts of NAD+.
 
According to many scientists and doctors dealing with healthy aging, maintaining higher levels of NAD+ is essential to extending our lives in good health.

NIACINAMIDE FULL BENEFITS

Precursor of NADH/NAD+ (nicotinamide adenine dinucleotide)

 

  • Supports breakdown of sugars and fats for energy[1]
  • Supports mitochondrial production of ATP[1]
  • NADH is part of complex I NADH/coenzyme Q reductase) of the mitochondrial electron transport chain[2]

 

Precursor of NADPH/NADP+ (nicotinamide adenine dinucleotide phosphate)

 

  • NADPH is a key cofactor for cytochrome P450 enzymes that detoxify xenobiotics[3]
  • NADPH is a cofactor for glutathione reductase, which maintains the levels of reduced glutathione - confers protection against oxidative stress[4]
  • Essential for the functioning of a wide range of enzymes involved in redox reactions[1]

 

Anti-aging

 

  • Influences lifespan, senescence, cell proliferation, apoptosis[1]
  • NAD+ is a substrate for sirtuins (SIRT-1 to SIRT-7), which promote healthspan[5]
  • NAD+ is a substrate for poly(ADP-ribose) polymerase-1(PARP-1), which is involved in DNA repair and essential for genome stability[5,6]
  • NAD+ supports mitochondrial function[7,8]
  • NAD+ supports stem cell function[8]
  • NAD+ extends lifespan (Caenorhabditis elegans and mice)[7,8]

 

Neuroprotection

 

  • Protects neuronal cells against ischemia and oxidative stress[9,10]

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REFERENCES

[1] A. A. Sauve, J. Pharmacol. Exp. Ther. 324, 883–893 (2008).
[2] N. Pollak, C. Dölle, M. Ziegler, Biochem. J. 402, 205–218 (2007).
[3] A. V. Pandey, C. E. Flück, Pharmacol. Ther. 138, 229–254 (2013).
[4] G. Filomeni, G. Rotilio, M. R. Ciriolo, Biochem. Pharmacol. 64, 1057–1064 (2002).
[5] A. R. Mendelsohn, J. W. Larrick, Rejuvenation Res. 20, 244–247 (2017).
[6] J. B. Kirkland, Nutr. Cancer. 46, 110–118 (2003).
[7] L. Mouchiroud et al., Cell. 154, 430–441 (2013).
[8] H. Zhang et al., Science. 352, 1436–1443 (2016).
[9] P. K. Shetty, F. Galeffi, D. A. Turner, Neurobiol. Dis. 62, 469–478 (2014).
[10] M. R. Hoane, D. R. Gilbert, M. A. Holland, J. L. Pierce, Neurosci. Lett. 408, 35–39 (2006).