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N-ACETYL-L-TYROSINE BENEFITS

KEY BENEFITS OF N-ACETYL-L-TYROSINE

    • Supports working memory, mental flexibility, and information processing
    • Supports a healthy stress response
    • Supports skin health

      • Supports brain function
    • Supports adaptation to stressful circumstances


ABOUT IS N-ACETYL-L-TYROSINE

N-acetyl-L-tyrosine (NALT) is a type of acetylated L-tyrosine. NALT (along with L-tyrosine) acts as a precursor to the neurotransmitter dopamine, so it is used as a nootropic.

 

There is a strong link between dopamine and reward, motivation, and pleasure, and it is an essential neurotransmitter in modulating focus, motivation, cognitive flexibility, and emotion.

 

Besides being a key regulator of creative-productive powers and states, dopamine is also a key regulator of motor control and coordination, so it is also crucial for muscle strength and performance.

 

When performing more demanding or stressful tasks[1], NALT (or other sources of L-tyrosine) may be particularly useful for cognitive support.

 

One study found that oral NALT significantly increased L-tyrosine[2] levels in the brain.


N-ACETYL-L-TYROSINE FULL BENEFITS

Brain function

 

  • Supports working memory[13–19]

  • Supports cognitive flexibility[20]

  • Supports logical reasoning[14]

  • Supports mathematical processing[14]

  • Supports convergent ("deep") thinking—a component of creativity[21]

  • Supports perceptual-motor task performance[15,22]

  • Supports inhibition of behavioral responses—a cognitive control function[23]

  • Precursor for catecholamine synthesis [dopamine, noradrenaline, and adrenaline][4]

  • Supports the rate of dopamine synthesis and release upon neuronal activation[5–10]

  • Supports norepinephrine synthesis and release upon neuronal activation[10–12]

  • Protects from neurotransmitter (DA, NE) depletion due to increased brain activity[1]

  • Protects from performance decline during cognitively demanding tasks[1]

 

Stress

 

  • Protects from the negative effects of stress on cognitive performance[15–18,22]

  • Protects from adverse behavioral responses to environmental stress[24]

  • Protects from stress-induced decreases in norepinephrine levels[25]

  • Protects from stress-induced increases in blood pressure[15,22]

  • Supports global mood[26]

N-ACETYL-L-TYROSINE CAN BE FOUND IN:

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REFERENCES

[1] B.J. Jongkees, B. Hommel, S. Kühn, L.S. Colzato, J. Psychiatr. Res. 70 (2015) 50–57.
[2] G. Topall, H. Laborit, J. Pharm. Pharmacol. 41 (1989) 789–791.
[3] S.C. Daubner, T. Le, S. Wang, Arch. Biochem. Biophys. 508 (2011) 1–12.
[4] J.D. Fernstrom, M.H. Fernstrom, J. Nutr. 137 (2007) 1539S–1547S; discussion 1548S.
[5] S.Y. Tam, J.D. Elsworth, C.W. Bradberry, R.H. Roth, J. Neural Transm. Gen. Sect. 81 (1990) 97–110.
[6] R.J. Wurtman, F. Larin, S. Mostafapour, J.D. Fernstrom, Science 185 (1974) 183–184.
[7] M.C. Scally, I. Ulus, R.J. Wurtman, J. Neural Transm. 41 (1977) 1–6.
[8] J.D. Milner, R.J. Wurtman, Neurosci. Lett. 59 (1985) 215–220.
[9] M.J. During, I.N. Acworth, R.J. Wurtman, J. Neurochem. 52 (1989) 1449–1454.
[10] T. Oishi, R.J. Wurtman, J. Neural Transm. 53 (1982) 101–108.
[11] S.K. Yeghiayan, S. Luo, B. Shukitt-Hale, H.R. Lieberman, Physiol. Behav. 72 (2001) 311–316.
[12] C.J. Gibson, R.J. Wurtman, Life Sci. 22 (1978) 1399–1405.
[13] L.S. Colzato, B.J. Jongkees, R. Sellaro, B. Hommel, Front. Behav. Neurosci. 7 (2013) 200.
[14] R.A. Magill, W.F. Waters, G.A. Bray, J. Volaufova, S.R. Smith, H.R. Lieberman, N. McNevin, D.H. Ryan, Nutr. Neurosci. 6 (2003) 237–246.
[15] J.B. Deijen, J.F. Orlebeke, Brain Res. Bull. 33 (1994) 319–323.
[16] C.R. Mahoney, J. Castellani, F.M. Kramer, A. Young, H.R. Lieberman, Physiol. Behav. 92 (2007) 575–582.
[17] C. O’Brien, C. Mahoney, W.J. Tharion, I.V. Sils, J.W. Castellani, Physiol. Behav. 90 (2007) 301–307.
[18] D. Shurtleff, J.R. Thomas, J. Schrot, K. Kowalski, R. Harford, Pharmacol. Biochem. Behav. 47 (1994) 935–941.
[19] J.R. Thomas, P.A. Lockwood, A. Singh, P.A. Deuster, Pharmacol. Biochem. Behav. 64 (1999) 495–500.
[20] L. Steenbergen, R. Sellaro, B. Hommel, L.S. Colzato, Neuropsychologia 69 (2015) 50–55.
[21] L.S. Colzato, A.M. de Haan, B. Hommel, Psychol. Res. 79 (2015) 709–714.
[22] J.B. Deijen, C.J. Wientjes, H.F. Vullinghs, P.A. Cloin, J.J. Langefeld, Brain Res. Bull. 48 (1999) 203–209.
[23] L.S. Colzato, B.J. Jongkees, R. Sellaro, W.P.M. van den Wildenberg, B. Hommel, Neuropsychologia 62 (2014) 398–402.
[24] L.E. Banderet, H.R. Lieberman, Brain Res. Bull. 22 (1989) 759–762.
[25] H. Lehnert, D.K. Reinstein, B.W. Strowbridge, R.J. Wurtman, Brain Res. 303 (1984) 215–223.
[26] L.A. Palinkas, K.R. Reedy, M. Smith, M. Anghel, G.D. Steel, D. Reeves, D. Shurtleff, H.S. Case, N. Van Do, H.L. Reed, Int. J. Circumpolar Health 66 (2007) 401–417.