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L-CITRULLINE

TOP BENEFITS OF L-CITRULLINE

        • Neuroprotective effect [3]
        • Improvement in erectile dysfunction [4]
        • Enhance heart functioning [4]
        • Support immune system [4]

WHAT IS L-CITRULLINE?

The amino acid L-Citrulline is classified as a non-essential amino acid. L-Citrulline is converted by your kidneys into L-arginine, an amino acid, and nitric oxide, a gas. These substances are essential for the health of your heart and blood vessels.
They might also help to strengthen your immune system.

 

The amino acid L-Citrulline increases the generation of nitric oxide in the body. Nitric oxide aids in the relaxation and function of your arteries, resulting in improved blood flow throughout your body. This could be beneficial in the prevention of certain disorders.

 

There is some evidence that this supplement may assist patients with high blood pressure to lower their blood pressure [1].


It is also created as a by-product of the reaction catalysed by the enzyme NO synthase from L-arginine. While an amino acid, L-Citrulline is not involved in protein synthesis and is not one of the amino acids that DNA codes for.

 

Although L-Citrulline cannot be integrated into proteins during their synthesis, it is known to exist as an amino acid in several proteins. Peptidylarginine deiminases (PADs), a family of enzymes that convert the amino acid arginine to citrulline, produce these citrulline residues. Myelin basic protein (MBP), fillagrin, and other histone proteins all include citrulline residues [2].


L-CITRULLINE KEY MECHANISMS

Brain

 

  • Prevent cerebrovascular injury [3]
  • Prevent neuronal cell death [3]
  • Maximize brain performance [4]
  • Enhance cognition [4]
  • Maximize oxygen and blood flow to the brain [4]

 

Heart

 

  • Improve the functioning of the heart [4]
  • Lower blood pressure [5]

 

Skin

 

  • Improvement of skin aging [6]
  • Protect skin from extreme conditions [6]
  • Aids wound healing [6]

 

Immune System

 

  • Fight foreign invaders [4]
  • Fight infection [4]

 

Reproductive System

 

  • Improvement in erectile dysfunction [4]
  • Beneficial effect on maternal vascular health [7]

 

GIT

 

  • Prevent short bowel problems [1]

 

Muscles

 

  • Aid in building muscles [1]

 

Kidney

 

  • Increases renal nitric oxide levels and reduce blood pressure [8]
  • Antioxidant activity [8]
  • Anti-inflammatory activity [8]

L-CITRULLINE CAN BE FOUND IN:

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REFERENCES

[1] K. Miller, "L-citrulline," WebMD, 24 September 2021. [Online]. Available: https://www.webmd.com/vitamins-and-supplements/l-citrulline-uses-and-risks. [Accessed 20 November 2021].
[2] "Citrulline," Drug Bank, 2021. [Online]. Available: https://go.drugbank.com/drugs/DB00155. [Accessed 20 November 2021].
[3] K.-E. L. a. Y.-S. Kang, "Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)," Pubmed, vol. 24, 2017.
[4] "Top 6 Health Benefits of L-Citrulline," One Peak Medical, [Online]. Available: https://www.onepeakmedical.com/benefits-of-l-citrulline/. [Accessed 20 November 2021].
[5] "Health Benefits of Citrulline," WebMD, [Online]. Available: https://www.webmd.com/diet/health-benefits-citrulline#1. [Accessed 20 November 2021].
[6] E. C. F. A. Machado, Nutraceuticals for Healthy Skin Aging, 2017.
[7] E. F. S. Mary Gemmel, "l-Citrulline supplementation during pregnancy improves perinatal and postpartum maternal vascular function in a mouse model of preeclampsia," American Journal Of Physiology, 2021.
[8] M. Shilstone, "Unlikely amino acid may have star qualities," 16 JAN 2019. [Online]. Available: https://www.nola.com/entertainment_life/health_fitness/article_5a92eaee-8307-5059-91f2-e0cf483e2c25.html. [Accessed 20 Novemebr 2021].