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GOTU KOLA ( CENTELLA ASIATICA ) WHOLE HERB EXTRACT benefits

KEY BENEFITS OF GOTU KOLA

    • Supports a healthy stress response*
    • Supports mental alertness and attention*
    • Supports circulation*
    • Supports a calm mood and feelings of contentment*

ABOUT GOTU KOLA

To counter mental fatigue and improve thinking, gotu kola (Centella asiatica; synonym: Hydrocotyle asiatica) is traditionally used as a tonic herb in Ayurvedic medicine as a mental rejuvenator (medhya Rasayana). During times of increased mental demands, it was considered particularly useful.

 

Traditionally, it has been used as a blood purifier, skin regenerator, and general longevity aid. The benefits of gotu kola have been proven in modern science - it is both a nootropic and a rejuvenator that promotes neuronal regeneration. Additionally, it supports healthy blood flow and veins.

 

In comparison with many other nootropics, Gotu Kola is perfect for taking at the end of a hectic day since it is soothing and supports repair and rejuvenation.

 

The main bioactive compounds in gotu kola are asiaticoside, asiatic acid, madecassic acid, madecassoside, and centelloside. Other compounds found in the Gotu kola plant are ursolic acid, rosemarinic acid, apigenin, and rutin[1]. As well as these compounds, Gotu kola contains other chemicals with biological activity.


GOTU KOLA FULL BENEFITS

Mood and stress response

 

  • Supports a calm mood[2–8]
  • Supports healthy behavioral and physiological responses to stress[8]

 

Brain function

 

  • Supports maintenance of healthy blood glucose levels [18–20]
  • Supports maintenance of healthy blood lipid levels [18–20]
  • Supports maintenance of healthy insulin signaling [21]
  • Supports healthy body fat levels [21]
  • Supports working memory[4]
  • Supports learning and memory[9–15]
  • Supports executive function[10,11]
  • Supports glutamate decarboxylase (GAD) activity[16]
  • Supports GABAergic neurotransmission[17]
  • Supports GABA receptor agonist actions [asiatic acid][18–20]
  • Supports glutamatergic AMPA receptors [9]
  • Down-regulates acetylcholinesterase (AChE)[14,18]
  • Supports hippocampal synaptic density[11]
  • Supports the expression of synaptic markers in the hippocampus and frontal cortex[21]
  • Supports brain mitochondrial function[10,11,14,21,22]
  • Supports brain-derived neurotrophic factor (BDNF)[12,13,23,24]
  • Supports NMDA receptors[24]
  • Supports hippocampal long-term potentiation[24]
  • Supports Nrf2 signaling in the brain[10,11,21,22]
  • Supports antioxidant defenses[7,10,11,14,21,22,25]
  • Supports neuroprotective functions[26]

 

Immune system

 

  • Supports innate immunity[27]
  • Supports adaptive immunity[28,29]

GOTU KOLA CAN BE FOUND IN:

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REFERENCES

[1] K.J. Gohil, J.A. Patel, A.K. Gajjar, Indian J. Pharm. Sci. 72 (2010) 546–556.
[2] U. Jana, T.K. Sur, L.N. Maity, P.K. Debnath, D. Bhattacharyya, Nepal Med. Coll. J. 12 (2010) 8–11.
[3] P. Puttarak, P. Dilokthornsakul, S. Saokaew, T. Dhippayom, C. Kongkaew, R. Sruamsiri, A. Chuthaputti, N. Chaiyakunapruk, Sci. Rep. 7 (2017) 10646.
[4] J. Wattanathorn, L. Mator, S. Muchimapura, T. Tongun, O. Pasuriwong, N. Piyawatkul, K. Yimtae, B. Sripanidkulchai, J. Singkhoraard, J. Ethnopharmacol. 116 (2008) 325–332.
[5] J. Bradwejn, Y. Zhou, D. Koszycki, J. Shlik, J. Clin. Psychopharmacol. 20 (2000) 680–684.
[6] K.V. Mitha, S. Yadav, B. Ganaraja, Indian J. Physiol. Pharmacol. 60 (2016) 167–173.
[7] P. Chanana, A. Kumar, Phytother. Res. 30 (2016) 671–680.
[8] A. Wanasuntronwong, M.H. Tantisira, B. Tantisira, H. Watanabe, J. Ethnopharmacol. 143 (2012) 579–585.
[9] N.A. Binti Mohd Yusuf Yeo, S. Muthuraju, J.H. Wong, F.R. Mohammed, M.H. Senik, J. Zhang, S.R. Yusof, H. Jaafar, M.L. Adenan, H. Mohamad, T.S. Tengku Muhammad, J.M. Abdullah, Brain Behav. 8 (2018) e01093.
[10] N.E. Gray, J.A. Zweig, M. Caruso, J.Y. Zhu, K.M. Wright, J.F. Quinn, A. Soumyanath, Mol. Cell. Neurosci. 93 (2018) 1–9.
[11] N.E. Gray, J.A. Zweig, M. Caruso, M.D. Martin, J.Y. Zhu, J.F. Quinn, A. Soumyanath, Brain Behav. 8 (2018) e01024.
[12] D.C.R. Sari, N. Arfian, U. Tranggono, W.A.W. Setyaningsih, M.M. Romi, N. Emoto, Iran. J. Basic Med. Sci. 22 (2019) 1218–1224.
[13] G. Sbrini, P. Brivio, M. Fumagalli, F. Giavarini, D. Caruso, G. Racagni, M. Dell’Agli, E. Sangiovanni, F. Calabrese, Nutrients 12 (2020).
[14] A. Kumar, A. Prakash, S. Dogra, Int. J. Alzheimers. Dis. 2011 (2011) 347569.
[15] M.N. Nasir, M. Habsah, I. Zamzuri, G. Rammes, J. Hasnan, J. Abdullah, J. Ethnopharmacol. 134 (2011) 203–209.
[16] R. Awad, D. Levac, P. Cybulska, Z. Merali, V.L. Trudeau, J.T. Arnason, Canadian Journal of Physiology and Pharmacology 85 (2007) 933–942.
[17] T.K. Chatterjee, A. Chakraborty, M. Pathak, G.C. Sengupta, Indian J. Exp. Biol. 30 (1992) 889–891.
[18] M.N. Nasir, J. Abdullah, M. Habsah, R.I. Ghani, G. Rammes, Phytomedicine 19 (2012) 311–316.
[19] T.E. Ceremuga, D. Valdivieso, C. Kenner, A. Lucia, K. Lathrop, O. Stailey, H. Bailey, J. Criss, J. Linton, J. Fried, A. Taylor, G. Padron, A.D. Johnson, AANA J. 83 (2015) 91–98.
[20] K. Hamid, I. Ng, V.J. Tallapragada, L. Váradi, D.E. Hibbs, J. Hanrahan, P.W. Groundwater, Chem. Biol. Drug Des. 88 (2016) 386–397.
[21] N.E. Gray, C.J. Harris, J.F. Quinn, A. Soumyanath, J. Ethnopharmacol. 180 (2016) 78–86.
[22] N.E. Gray, J.A. Zweig, D.G. Matthews, M. Caruso, J.F. Quinn, A. Soumyanath, Oxid. Med. Cell. Longev. 2017 (2017) 7023091.
[23] M. Ar Rochmah, I.M. Harini, D.E. Septyaningtrias, D.C.R. Sari, R. Susilowati, Biomed Res. Int. 2019 (2019) 2649281.
[24] Y. Boondam, P. Songvut, M.H. Tantisira, S. Tapechum, K. Tilokskulchai, N. Pakaprot, Sci. Rep. 9 (2019) 8404.
[25] N. Haleagrahara, K. Ponnusamy, J. Toxicol. Sci. 35 (2010) 41–47.
[26] S. Chen, Z.-J. Yin, C. Jiang, Z.-Q. Ma, Q. Fu, R. Qu, S.-P. Ma, Pharmacol. Biochem. Behav. 122 (2014) 7–15.
[27] M.G. Jayathirtha, S.H. Mishra, Phytomedicine 11 (2004) 361–365.
[28] D. Arora, M. Kumar, S.D. Dubey, U. Sings, Anc. Sci. Life 22 (2002) 42–48.
[29] K. Punturee, C.P. Wild, W. Kasinrerk, U. Vinitketkumnuen, Asian Pac. J. Cancer Prev. 6 (2005) 396–400.