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- Supports cardiovascular function
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Supports genetic stability
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Supports production and maintenance of new cells
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Supports genetic stability
Supports production and maintenance of new cells
Cellular function
Folate coenzymes mediate the transfer of one-carbon units (one-carbon metabolism) [6,7]
Folate coenzymes act as cofactors for several enzymes involved in key metabolic pathways, specifically in nucleic acid (DNA and RNA) and amino acid metabolism [6,7]
Methyltetrahydrofolate is used by the cytosolic enzyme methionine synthase to generate methionine and tetrahydrofolate from homocysteine [6,7]
Methionine is required for the synthesis of S-adenosylmethionine (SAMe), a methyl group donor used in many biological methylation reactions [6,7]
Methionine synthase is essential for the methylation of nucleic acids (DNA and RNA) and proteins [6,7]
Adequate folate status is needed to maintain NAD+ levels [8–10]
Brain function
Supports healthy cognitive function [11–16]
Supports neurotransmitter synthesis (e.g., dopamine, norepinephrine, serotonin) [17,18]
Supports healthy blood-brain barrier function [19]
Supports neuroprotective and neuronal repair functions [20–25]
Supports a healthy mood and positive outlook [26–30]
Cardiovascular and cerebrovascular function
Complementary ingredients
Vitamin B12 - The main safety concern associated with high doses of folic acid supplementation is that it might mask a vitamin B12 deficiency. Because of this, vitamin B12 is often given in combination with folic acid, especially if higher amounts of folic acid or other folates are used.
Methyl Donors - Key methyl donor nutrients include trimethylglycine (betaine), folates, vitamin B6, vitamin B12, and S-adenosylmethionine: One or more of these nutrients are often given together.
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