• Supports cardiovascular function
      • Supports genetic stability

      • Supports production and maintenance of new cells


Folate or vitamin B9, is primarily biologically active as L-5'-methyltetrahydrofolate (L-5-MTHF).
In addition to folic acid, this vitamin is also available in the form of folinic acid (also known as calcium folinate).
Folates get their name from the Latin word for leaf (folium), which is why leafy greens (e.g., lettuce, spinach) are nutritionally dense foods. Other good sources of folate include beans, lentils, nuts, and seeds.
There is a folate form in circulation called L-5-MTHF, which crosses the blood-brain barrier.
Folate plays an active role in DNA expression and repair, which is essential for the maintenance and production of new cells.
Folate plays a crucial role in a process known as methylation or methyl donation. This process plays an active role in metabolic function.
Methylation, for example, is one of the most common ways genes are expressed in response to the environment, diet, and lifestyle we lead.


Cellular function


  • Folate coenzymes mediate the transfer of one-carbon units (one-carbon metabolism) [6,7]

  • Folate coenzymes act as cofactors for several enzymes involved in key metabolic pathways, specifically in nucleic acid (DNA and RNA) and amino acid metabolism [6,7]

  • Methyltetrahydrofolate is used by the cytosolic enzyme methionine synthase to generate methionine and tetrahydrofolate from homocysteine [6,7]

  • Methionine is required for the synthesis of S-adenosylmethionine (SAMe), a methyl group donor used in many biological methylation reactions [6,7]

  • Methionine synthase is essential for the methylation of nucleic acids (DNA and RNA) and proteins [6,7]

    Adequate folate status is needed to maintain NAD+ levels [8–10]


Brain function


  • Supports healthy cognitive function [11–16]

  • Supports neurotransmitter synthesis (e.g., dopamine, norepinephrine, serotonin) [17,18]

  • Supports healthy blood-brain barrier function [19]

  • Supports neuroprotective and neuronal repair functions [20–25]

  • Supports a healthy mood and positive outlook [26–30]


Cardiovascular and cerebrovascular function


  • Influences homocysteine levels (supports protection of cardiovascular function); complementary to vitamin B6 and vitamin B12 [31–33]


Complementary ingredients


  • Vitamin B12 - The main safety concern associated with high doses of folic acid supplementation is that it might mask a vitamin B12 deficiency. Because of this, vitamin B12 is often given in combination with folic acid, especially if higher amounts of folic acid or other folates are used.

  • Methyl Donors - Key methyl donor nutrients include trimethylglycine (betaine), folates, vitamin B6, vitamin B12, and S-adenosylmethionine: One or more of these nutrients are often given together.


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