• Supports healthy aging

        • Supports cellular health


Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a plant flavonol belonging to the flavonoid polyphenol group. It is a yellow plant pigment, with its name originating from a German word (fisetholz) for a traditional yellow dye called “young fustic.”


Polyphenols, like fisetin, play important roles in the plant kingdom. One of these roles is protecting plants from environmental stress. Because of this, fisetin is found in many plants, occurring in their green parts, fruits, barks, and hardwood.


Fisetin is present in strawberries, apples, persimmon, grapes, onions, and cucumbers, as examples, though in very low amounts. Most of the research on fisetin has focused on its potential to support senolytic mechanisms and neuroprotective functions.*


Fisetin is produced from the stems of Rhus succedanea (Japanese fruit wax tree), which is the primary commercial source used to make this dietary supplement ingredient. The high-purity standardized extract we use contains not less than 98% fisetin.


Fisetin is non-GMO, gluten-free, vegan, and Kosher and Halal certified.



  • Supports healthy brain aging

  • Supports cognition of senescence-accelerated mice [1]

  • Supports synaptic function [1]

  • Supports stress markers [1]

  • Supports immune signaling [1,2]

  • Supports relative α-power, β-power, and multi-unit activity count (aged rats) [3]

  • Supports cognitive and behavioral performance of aged rats [3]

  • Supports antioxidant defenses (aged rats and aging model) [2,4]

  • Supports Sirt1/Nrf2 signaling (aging model) [2]

  • Influences NF-kB pathway (aging model) [2]

  • Supports mitochondrial function (aged rats) [4]

  • Supports autophagy (aged rats) [4]


    Promotes healthy aging and longevity

  • Restores tissue homeostasis (late life mice) [5]

  • Supports liver antioxidant defenses [5]

  • Supports the management of senescent cells [5]

  • Supports cellular functions involved with pruning stressed cells [6–12]

  • Supports autophagy [4,13–17]

  • Supports mitophagy [18,19]

  • Supports immune signaling [15,19,20]


    Supports cellular signaling

  • Influences PI3K/AKT [11,14,15,21–23]

  • Influences mTOR signaling [11,13–15,21–23]

  • Influences AMPK signaling [13,14,16,24,25]

  • Influences SIRT1 signaling [16]

  • Influences NF-κB signaling [6,26–29]

  • Influences HIF-1α [8,30]


    Complementary ingredients

    Luteolin in influencing immune signaling [31,32]


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