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Forskohlii / Indian coleus BENEFITS

KEY BENEFITS OF COLEUS FORSKOHLII

    • Supports healthy cellular responses
    • Supports healthy weight and bone structure
    • Supports antioxidant defenses
    • Supports cognitive performance
    • Supports cardiovascular function

ABOUT COLEUS FORSKOHLII

Plectranthus barbatus, also known as Coleus forskohlii (taxonomically similar), is used widely in traditional medicine throughout the world, typically in Ayurvedic medicine.

 

In India, it is used as a condiment herb and belongs to the same family as mint and lavender.

 

As a traditional remedy, C.forskohlii is used to support the function and health of the digestive, liver, respiratory, cardiovascular, and nervous systems.

 

Coleonol, or forskolin, is a unique compound found in the root of C.forskohlii. cAMP (cyclic adenosine monophosphate) is an important signaling molecule inside cells that plays key roles in several important signaling pathways and physiological functions [1–3]. Forskolin regulates the adenylate cyclase enzyme by promoting its activity, which leads to an increase in the levels of cyclic adenosine monophosphate (cAMP).


COLEUS FORSKOHLII FULL BENEFITS

Cellular function

 

  • Supports the adenylate cyclase enzyme [4–6]

 

Brain function    

 

  • Influences acetylcholinesterase activity – supports acetylcholine levels [7–9]
  • Supports late LTP (via cAMP and the mTOR pathway) [10]
  • Influences neural cytokine signaling [11]

 

Heart and vascular health

 

  • Influences platelet aggregation [12–14]
  • Supports vasodilation [14]
  • Supports healthy blood pressure [14–16]
  • Supports cardiac muscle strength (positive inotropic activity) [14]

 

General health

 

  • Supports metabolic function [17,18]
  • Supports lipolysis (via cAMP upregulation) [5]
  • Supports healthy body composition [18,19]
  • Supports bone health [17,18,20]
  • Supports antioxidant and free radical scavenging activities [7,21,22]
  • Supports immune signaling [11,22]

COLEUS FORSKOHLII CAN BE FOUND IN:

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REFERENCES

[1]R.H. Alasbahi, M.F. Melzig, Planta Med. 76 (2010) 653–661.
[2]R.H. Alasbahi, M.F. Melzig, Planta Med. 76 (2010) 753–765.
[3]C.W. Lukhoba, M.S.J. Simmonds, A.J. Paton, J. Ethnopharmacol. 103 (2006) 1–24.
[4]K.B. Seamon, W. Padgett, J.W. Daly, Proc. Natl. Acad. Sci. U. S. A. 78 (1981) 3363–3367.
[5]I. Litosch, T.H. Hudson, I. Mills, S.Y. Li, J.N. Fain, Mol. Pharmacol. 22 (1982) 109–115.
[6]K.B. Seamon, Drug Dev. Res. 6 (1985) 181–192.
[7]S. Porfírio, P.L.V. Falé, P.J.A. Madeira, M.H. Florêncio, L. Ascensão, M.L.M. Serralheiro, Food Chem. 122 (2010) 179–187.
[8]P.L. Falé, C. Borges, P.J.A. Madeira, L. Ascensão, M.E.M. Araújo, M.H. Florêncio, M.L.M. Serralheiro, Food Chem. 114 (2009) 798–805.
[9]P.L.V. Falé, P.J.A. Madeira, M.H. Florêncio, L. Ascensão, M.L.M. Serralheiro, Food Funct. 2 (2011) 130–136.
[10]D. Gobert, L. Topolnik, M. Azzi, L. Huang, F. Badeaux, L. Desgroseillers, W.S. Sossin, J.-C. Lacaille, J. Neurochem. 106 (2008) 1160–1174.
[11]T. Veremeyko, A.W.Y. Yung, M. Dukhinova, I.S. Kuznetsova, I. Pomytkin, A. Lyundup, T. Strekalova, N.S. Barteneva, E.D. Ponomarev, Front. Immunol. 9 (2018) 50.
[12]A.M. Siegl, J.W. Daly, J.B. Smith, Mol. Pharmacol. 21 (1982) 680–687.
[13]S. Adnot, M. Desmier, N. Ferry, J. Hanoune, T. Sevenet, Biochem. Pharmacol. 31 (1982) 4071–4074.
[14]N.J. de Souza, A.N. Dohadwalla, J. Reden, Med. Res. Rev. 3 (1983) 201–219.
[15]M. Jagtap, H.M. Chandola, B. Ravishankar, Ayu 32 (2011) 59–65.
[16]M.P. Dubey, R.C. Srimal, S. Nityanand, B.N. Dhawan, J. Ethnopharmacol. 3 (1981) 1–13.
[17]H.L. Loftus, K.J. Astell, M.L. Mathai, X.Q. Su, Nutrients 7 (2015) 9508–9522.
[18]M.P. Godard, B.A. Johnson, S.R. Richmond, Obes. Res. 13 (2005) 1335–1343.
[19]S. Henderson, B. Magu, C. Rasmussen, S. Lancaster, C. Kerksick, P. Smith, C. Melton, P. Cowan, M. Greenwood, C. Earnest, A. Almada, P. Milnor, T. Magrans, R. Bowden, S. Ounpraseuth, A. Thomas, R.B. Kreider, J. Int. Soc. Sports Nutr. 2 (2005) 54–62.
[20]J. Doorn, R. Siddappa, C.A. van Blitterswijk, J. de Boer, Tissue Eng. Part A 18 (2012) 558–567.
[21]V.K. Bajpai, Y.-H. Park, P. Agrawal, Frontiers in Life Science 8 (2015) 139–147.
[22]D.B. Menon, K. Latha, Pharmacognosy Journal 3 (2011) 75–79.