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Cinnamon | Indonesian Cassia BENEFITS

KEY BENEFITS OF CINNAMON EXTRACT

  • Supports healthy gut microbiota
  • Supports healthy blood sugar levels
  • Supports metabolic health
  • Supports healthy weight
  • Supports healthy blood pressure
  • Supports cellular responses
  • Supports healthy aging
  • Supports antioxidant defenses
  • Supports women’s hormone balance

ABOUT CINNAMON EXTRACT

A spice as old as cinnamon, cinnamon is one of the oldest in the world. It played a significant role in the spice trade between Asia and Europe, along with pepper and ginger.

 

This spice is derived from the inner bark of many tree species in the Cinnamomum genus. Indian, Sri Lankan, Indonesian, and Burmese cinnamon trees represent the various species of this tree.

 

Despite the similarity of the cinnamon species, they produce different extracts. Among the reasons we chose Cinnulin PF®-a standardized Cinnamomum burmannii bark extract-were (1) that it has been evaluated in clinical trials, and (2) because it is monitored for its coumarin content, which should not exceed 0.7%.


CINNAMON EXTRACT FULL BENEFITS

Metabolism

 

  • Supports healthy insulin sensitivity [1–8]
  • Upregulates the insulin signaling pathway  [1, 3, 9]
  • Upregulates the glucose transporter GLUT-4 [10–12]
  • Downregulates fat accumulation and blood/liver lipid levels [1, 4, 7–9, 11, 13, 14]
  • Upregulates lean mass [15]
  • Upregulates adiponectin levels [1]

 

Signaling pathways

 

  • Upregulates AMP-activated protein kinase (AMPK) signaling [4, 10, 16]
  • Upregulates liver kinase B1 (LKB1)  [10]
  • Upregulates peroxisome proliferator-activated receptor alpha (PPARα) and delta (PPARδ); modulates PPAR gamma (PPARγ) [4, 11, 17]

 

Antioxidant defenses*

 

  • Downregulates the production of reactive oxygen species and oxidative stress [13, 18, 19]
  • Upregulates antioxidant enzymes (superoxide dismutase [SOD]) [19]
  • Replenishes glutathione (GSH) levels [19]

 

Cellular signaling

 

  • Downregulates the expression of proinflammatory molecules (tumor necrosis factor alpha [TNFα], nuclear factor kappa B [NF-κB], interleukin 1β [IL-1β], IL-6) [3, 20, 21]
  • Protects mitochondrial structure and function [22, 23]

 

Gut microbiota

 

  • Regulates the composition of the gut microbiota [24, 25]
  • Supports gut barrier function [24]

 

Healthy aging and longevity

 

  • Neuroprotective effects [26]
  • Supports liver function [11]
  • Upregulates heat-shock protein 70 (HSP70) [27]
  • Upregulates SIRT1, SIRT2, and SIRT3 [20, 21]
  • Upregulates uncoupling protein 1 (UCP1) [12, 14]
  • Extends lifespan (Drosophila melanogaster) [27]

Cinnamon CAN BE FOUND IN:

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REFERENCES

[1] B. Qin, M. M. Polansky, R. A. Anderson, Horm. Metab. Res. 42, 187–193 (2010).
[2] J. G. Wang et al., Fertil. Steril. 88, 240–243 (2007).
[3] B. Qin, H. D. Dawson, N. W. Schoene, M. M. Polansky, R. A. Anderson, Nutrition. 28, 1172–1179 (2012).
[4] B. Huang, H. D. Yuan, D. Y. Kim, H. Y. Quan, S. H. Chung, J. Agric. Food Chem. 59, 3666–3673 (2011).
[5] M. Hajimonfarednejad et al., Phytother. Res. 32, 276–283 (2018).
[6] R. Zare, A. Nadjarzadeh, M. M. Zarshenas, M. Shams, M. Heydari, Clin. Nutr. (2018), doi:10.1016/j.clnu.2018.03.003.
[7] A. Borzoei, M. Rafraf, M. Asghari-Jafarabadi, Asia Pac. J. Clin. Nutr. 27, 556–563 (2018).
[8] R. A. Anderson et al., Afr. J. Tradit. Complement. Altern. Med. 6, 332–336 (2016).
[9] B. Qin, M. M. Polansky, Y. Sato, K. Adeli, R. A. Anderson, J. Nutr. Biochem. 20, 901–908 (2009).
[10] Y. Shen et al., PLoS One. 9, e87894 (2014).
[11] X. Sheng, Y. Zhang, Z. Gong, C. Huang, Y. Q. Zang, PPAR Res. 2008, 581348 (2008).
[12] Y. Shen et al., Biosci. Biotechnol. Biochem. 74, 2418–2425 (2010).
[13] A. Borzoei et al., Afr. J. Tradit. Complement. Altern. Med. 8, 128–133 (2018).
[14] Y. Tamura, Y. Iwasaki, M. Narukawa, T. Watanabe, J. Nutr. Sci. Vitaminol. . 58, 9–13 (2012).
[15] T. N. Ziegenfuss, J. E. Hofheins, R. W. Mendel, J. Landis, R. A. Anderson, J. Int. Soc. Sports Nutr. 3, 45–53 (2006).
[16] C. Kopp et al., Int. J. Mol. Sci. 15, 2906–2915 (2014).
[17] J.-E. Li et al., Am. J. Chin. Med. 43, 879–892 (2015).
[18] A.-M. Roussel, I. Hininger, R. Benaraba, T. N. Ziegenfuss, R. A. Anderson, J. Am. Coll. Nutr. 28, 16–21 (2009).
[19] A. S. Sahib, J Intercult Ethnopharmacol. 5, 108–113 (2016).
[20] B. Qin, K. S. Panickar, R. A. Anderson, Nutrition. 30, 210–217 (2014).
[21] B. Qin, K. S. Panickar, R. A. Anderson, Life Sci. 102, 72–79 (2014).
[22] K. Couturier et al., J. Nutr. Biochem. 28, 183–190 (2016).
[23] K. S. Panickar, M. M. Polansky, R. A. Anderson, Exp. Neurol. 216, 420–427 (2009).
[24] M. Van Hul et al., Am. J. Physiol. Endocrinol. Metab. 314, E334–E352 (2018).
[25] Q.-Y. Lu et al., J. Food Sci. 82, 1807–1813 (2017).
[26] D. W. Peterson et al., J. Alzheimers. Dis. 17, 585–597 (2009).
[27] S. E. Schriner et al., Exp. Gerontol. 60, 220–230 (2014).