- Supports mood
Supports stress response
- Supports cognitive performance
Supports stress response
The Indian celastrus paniculatus, or "the intellect tree," is primarily used by local healers as a brain tonic.
These uses are now recognized as nootropics. Among these benefits are "...mental acuity, support of memory and intellect, retention and recalling ability, and alleviation of mental fatigue, stress..."*
This plant was thought to improve people's ability to learn new information more rapidly, and to recall that information more accurately and efficiently, later on,*.
Cerlastrus paniculatus seeds (and its oil) are used to support cognitive functioning. Several active compounds have been detected in the seeds, including celastrine, celapanine, celapanigine, celapagin, malkangunin and paniculatine.
In experimental studies, Celastrus paniculatus extracts have shown positive effects on cognitive function and neuroprotection.*
Brain function and cognition
Supports memory and facilitates learning [2,5,7]
Counters experimentally-induced memory and learning impairments in animals [5,8–11]
Supports the levels of monoamine neurotransmitters (noradrenaline, dopamine and serotonin) and their metabolites in the brain 
Interacts with dopamine-D2, serotonergic, GABAB, and NMDA receptors [3,4]
Influences brain MAO-A levels 
Influences acetylcholinesterase activity in the brain 
Supports brain content of total lipids and phospholipids 
Supports neuroprotective functions [4,11,13,14]
Mood and stress
Supports positive behavioral responses to stress [3,8,12]
Influences plasma corticosterone (stress hormone) levels 
Supports antioxidant defenses [7,11,13–17]
Counters oxidative stress [7,11,13–17]
Supports free-radical-scavenging activity [14,16,18]
Supports healthy immune/cytokine signaling [17,19,20]
Supports relief of minor physical discomfort [19,20]
Supports gastroprotective functions 
Supports healthy cholesterol levels 
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