• Supports cognitive function*
    • Supports vision*
    • Supports antioxidant defenses*
    • Supports cardiometabolic health*


Blueberries are the fruit of a group of plant species belonging to the genus Vaccinium, section Cyanococcus. Blueberries contain anthocyanins that give the characteristic blue-purple color. They also contain other polyphenols and various phytochemicals. Commercial blueberries include wild (‘lowbush’) and cultivated (‘highbush’) varieties. Wild blueberries (Vaccinium angustifolium) are native to North American and are both smaller and have more intense color than the cultivated highbush blueberries. They also have higher anthocyanin and polyphenols content.[1,2] Most wild blueberries are harvested from native patches in Quebec, Nova Scotia, and Maine. Wild blueberry supplementation has primarily been studied for supporting cognitive function and brain health.[3,4]


Brain function


  • Supports memory in adults [3–5]
  • Supports memory and cognitive performance in children [6–9]
  • Supports mood [10]
  • Supports task-related brain activation [11]
  • Supports memory (animal studies) [12–15]
  • Supports dopaminergic neurotransmission [16–18]
  • Supports brain-derived neurotrophic factor (BDNF) [14,15,19–21]
  • Supports hippocampal IGF-1 levels [22]
  • Supports long-term potentiation (LTP) [23]
  • Supports neuroprotective functions [22,24,25]
  • Supports healthy brain aging [18,26,27]
  • Supports brain circulation [11]


Antioxidant defenses


  • Supports antioxidant enzymes in the brain (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]) [28–30]
  • Replenishes glutathione (GSH) [31]
  • Downregulates NADPH oxidase activity [32]
  • Supports free radical scavenging and antioxidant functions [28,33–35]


Cardiometabolic health


  • Supports cardiac function [36]
  • Supports vascular function [37]
  • Supports cardio-protective functions [38]
  • Supports endothelial nitric oxide (eNOS) activity [31]
  • Supports healthy blood pressure [3,28,39–41]
  • Downregulates LDL oxidation [35,39]
  • Supports healthy blood glucose levels [42]




  • Protects retinal photoreceptor cells from blue LED light-induced damage [43,44]
  • Protects against screen-induced ocular fatigue [45,46]


Exercise performance


  • Supports exercise performance [47]
  • Supports recovery from muscle damage [48]


Gut Microbiota


  • Supports the composition of the gut microbiota [49–56]
  • Supports microbial metabolism — short-chain fatty acid (SCFA) production [57]
  • Supports the intestinal epithelial barrier [52]


Healthy aging and longevity


  • Supports stem cell proliferation [58]
  • Prevents cell senescence [59]
  • Supports nuclear factor erythroid-2 related factor-2 (Nrf2) [29,30]
  • Supports DNA repair enzymes [29]
  • Protects against DNA damage [60–62]
  • Extends lifespan (Drosophila melanogaster) [63]


Immune System


  • Supports innate immune system [37,64–68]
  • Supports adaptive immune system [69]
  • Supports immune system communication [68,70,71]


Complementary ingredients


  • Grape extracts for support of cognitive function [72–75]
  • Grape extracts for blueberry/grape polyphenol bioavailability [76]
  • Green tea and soy protein for general immune health [77]


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