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AMERICAN GINSENG (CEREBOOST™) benefits

KEY BENEFITS OF PANAX QUINQUEFOLIUS

    • Supports cognitive function and performance
    • Promotes calmness
    • Enhances working memory and alertness

ABOUT PANAX QUINQUEFOLIUS

American ginseng is the common name for Panax quinquefolius, which is native to forested regions of North America.

 

In many ways, it shares many characteristics with Asian ginseng (Panax ginseng). As ginsenosides, both American and Asian ginsengs contain similar active ingredients.

 

As a result of ginsenosides, ginseng is thought to have adaptogenic qualities (i.e., support of fatigue and stress) and health-promoting properties. While there are many types of ginsenosides, the best known include Rb1, Rb2, Rg1, Rc, Rd, and Re.

 

Cereboost™ is an American ginseng root extract clinically studied and standardized. Cereboost™ has been shown to improve working memory and alertness in humans while promoting calmness.

PANAX QUINQUEFOLIUS FULL BENEFITS

Cognitive function

 

  • Supports attention [2]
  • Supports working memory [2,3]
  • Supports learning and memory [4–7]

 

Mood

 

  • Promotes calmness [2]
  • Supports mood [1,8,9]
  • Adaptogenic actions (i.e., stress resilience and anti-fatigue) [5]
  • Downregulates stress hormone levels / HPA-axis activation [1,8]

 

Brain function

 

  • Modulates cholinergic neurotransmission [1,4,5,10,11]
  • Downregulates acetylcholinesterase (AChE) activity [4]
  • Upregulates choline acetyltransferase (ChAT) expression [4]
  • Upregulates acetylcholine levels [4]
  • Modulates dopaminergic neurotransmission [12–15]
  • Modulates GABAergic neurotransmission [1,8]
  • Neuroprotective effects [1,4,5,8,10]
  • Regulates neural cytokine signaling [1,8,10,16]
  • Protects against glutamate neurotoxicity [10,17]
  • Supports neurite outgrowth, dendritic spine density, and synaptic plasticity [1,5–7]
  • Upregulates BDNF signaling [1,7,10,18]
  • Supports neurogenesis [1,10,18]

 

Antioxidant defenses

 

  • Upregulates antioxidant enzymes in the brain (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]) [8]
  • Replenishes glutathione (GSH) levels [8]
  • Downregulates lipid peroxidation [8]

 

Cardiometabolic effects

 

  • Supports healthy cardiometabolic parameters [19–21]
  • Supports healthy blood glucose levels [22–24]
  • Supports healthy insulin sensitivity [25]
  • Supports fat metabolism [19]
  • Supports mitochondrial enzyme complex activities [8]

 

Gut microbiota

 

  • Regulates gut cytokine signaling [26–28]
  • Modulates gut microbiota composition [27,28]

 

Ergogenic effects

 

  • Supports high-intensity endurance performance [29,30]
  • Protects from exercise-induced muscle damage [29–31]

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REFERENCES

[1] H.J. Kim, P. Kim, C.Y. Shin, J. Ginseng Res. 37 (2013) 8–29.
[2] A. Scholey, A. Ossoukhova, L. Owen, A. Ibarra, A. Pipingas, K. He, M. Roller, C. Stough, Psychopharmacology 212 (2010) 345–356.
[3] A. Ossoukhova, L. Owen, K. Savage, M. Meyer, A. Ibarra, M. Roller, A. Pipingas, K. Wesnes, A. Scholey, Hum. Psychopharmacol. 30 (2015) 108–122.
[4] K. Shin, H. Guo, Y. Cha, Y.-H. Ban, D.W. Seo, Y. Choi, T.-S. Kim, S.-P. Lee, J.-C. Kim, E.-K. Choi, J.-M. Yon, Y.-B. Kim, Regul. Toxicol. Pharmacol. 78 (2016) 53–58.
[5] Y. Cheng, L.-H. Shen, J.-T. Zhang, Acta Pharmacol. Sin. 26 (2005) 143–149.
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[27] C.-Z. Wang, C. Yu, X.-D. Wen, L. Chen, C.-F. Zhang, T. Calway, Y. Qiu, Y. Wang, Z. Zhang, S. Anderson, Y. Wang, W. Jia, C.-S. Yuan, Cancer Prev. Res. 9 (2016) 803–811.
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