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ALPHA GPC

TOP BENEFITS OF ALPHA-GLYCEROPHOSPHOCHOLINE

    • Supports cognitive function*
    • Enhance exercise performance*

WHAT IS ALPHA-GLYCEROPHOSPHOCHOLINE?

The chemical compound alpha-glycerophosphocholine (alpha-GPC) has choline-containing properties and can be used to increase the brain and body's levels of choline.

 

In this role it serves as a precursor for both acetylcholine and phosphatidylcholine biosynthesis.

 

The nootropic forms of choline are alpha-GPC and citicoline (i.e., CDP-choline). They increase brain choline levels, act as building blocks of acetylcholine, and support choline-dependent neurotransmission.

 

Alpha-GPC, however, contains a higher proportion of choline, so a lower dose of alpha-GPC provides more choline support than a similar dose of citicoline.

Alpha-GPC is therefore more effective by weight as a choline precursor. Alpha-GPC is metabolized into choline and phospholipid glycerophosphate following oral administration.

 

Acetylcholine is a key neurotransmitter in the brain; it's also used in the flight or fight response of the autonomic nervous system; and it is a signaling molecule that activates muscles.[3,8–13] Choline can be used to synthesize acetylcholine and to transmit it through neural pathways.

 

Because alpha-GPC is a precursor in the biosynthesis of acetylcholine, it plays a supportive role in a variety of cognitive functions, including attention, concentration, mental focus, and memory formation and recall.[15]*

 

Alpha-GPC also supports aspects of muscle performance, and is involved in maintaining organs and tissues.* And, because alpha-GPC can be readily metabolized into phosphatidylcholine, it can be used to support the structure and function of cell membranes. Alpha-GPC is found in low amounts in a variety of foods[16] and in breast milk.[17,18] effects [2–5].


ALPHA-GLYCEROPHOSPHOCHOLINE KEY MECHANISMS

Augments choline pool

 

  • Alpha-GPC is part of the CDP-choline (or Kennedy) pathway, which has a central role in choline homeostasis [13,14]
  • Supports plasma choline levels [20]
  • Precursor for phosphatidylcholine synthesis [3]
  • Precursor for acetylcholine synthesis [2,3]

 

Brain function

 

  • Supports memory and learning [7,27,36]
  • Supports attention [7,36]
  • Supports cognition [2,3,15,36,37]
  • Supports acetylcholine synthesis and release [2,3,21]
  • Supports vesicular acetylcholine transporter levels [21,22]
  • Supports high affinity choline uptake transporter levels [22]
  • Protects from age-related changes in cholinergic neurotransmission [23]
  • Supports dopamine synthesis and release [1,24]
  • Supports dopamine plasma membrane transporter (DAT) levels [24]
  • Supports serotonin synthesis [24]
  • Supports GABA release [25]
  • Supports phospholipid synthesis [9,26]
  • Supports phosphoinositide synthesis [26,27]
  • Supports protein kinase C (PKC) activation [28–30]
  • Supports growth hormone secretion from the pituitary gland [10,20,31]
  • Counters some age-related brain microstructural changes [32–35]
  • Supports neuroprotective functions [2,3]

 

Exercise performance

 

  • Supports isometric force production [38]
  • Supports maximum power and velocity in jump movements [19]

 

Complementary ingredients

 

  • CDP-choline, Uridine Monophosphate, Huperzine A, Bacopa monnieri, Celastrus paniculatus, Coleus forskohlii, Vitamin B5 in supporting cholinergic neurotransmission

ALPHA GPC CAN BE FOUND IN:

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REFERENCES

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